Enzymes

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rk386
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Enzymes

Post by rk386 » Mon Aug 06, 2012 3:36 pm

Do enzymes in the body last permanently, or do they over time get broken down and then replenished/rebuilt/replaced? Also, what controls the amount of enzyme present?
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jonmoulton
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Re: Enzymes

Post by jonmoulton » Tue Aug 07, 2012 3:32 pm

Enzymes are degraded over time. Some are relatively short-lived while others are very persistent, but damage accumulates and they are eventually broken down.

This page might help the system make more sense.

http://en.wikipedia.org/wiki/Proteolysis
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david23
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Re: Enzymes

Post by david23 » Tue Aug 07, 2012 10:08 pm

what controls the enzyme levels? your genes, and hormonal regulations which again your genes
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JackBean
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Post by JackBean » Tue Aug 07, 2012 10:16 pm

you seem to put everything under genes, but genes are controlled by many factors as well
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.
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rk386
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Re: Enzymes

Post by rk386 » Wed Aug 08, 2012 6:17 pm

Thanks. Follow-up question:

Enzymes are degraded over time. Some are relatively short-lived while others are very persistent, but damage accumulates and they are eventually broken down.

Is it known which types of enzymes break down quickly and which are persistent?
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JackBean
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Post by JackBean » Wed Aug 08, 2012 6:33 pm

Yes, there are soe well-known examples. For those you don't know about, you can make some predictions.
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.
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rk386
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Re: Enzymes

Post by rk386 » Wed Aug 08, 2012 9:47 pm

Thanks. If I wanted to look more into this, where would I look?
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JackBean
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Post by JackBean » Wed Aug 08, 2012 10:03 pm

The first choice should be Alberts' The Cell
http://www.biolib.cz/en/main/

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rk386
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Post by rk386 » Wed Aug 08, 2012 10:07 pm

Oh, great, I have that.
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jonmoulton
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Re: Enzymes

Post by jonmoulton » Thu Aug 09, 2012 3:19 pm

Look for "protein turnover". Here's an introduction. http://en.wikipedia.org/wiki/Protein_turnover
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rk386
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Post by rk386 » Wed Aug 15, 2012 4:04 pm

Thanks. Have studies on protein turnover been done for specific proteins, or is it just known in general that that is what happens?
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jonmoulton
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Post by jonmoulton » Wed Aug 15, 2012 4:50 pm

It has been done for many specific proteins. One good method is pulse-chase analysis. http://en.wikipedia.org/wiki/Pulse-chase_analysis
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