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hydrochloric acid

Posted: Mon Nov 21, 2005 9:26 pm
by burningredphoenix
it's in the body, but where does body get it frm, it can't get it from salt

Posted: Mon Nov 21, 2005 9:29 pm
by Poison
Why not from salt? salt is NaCl.

Posted: Mon Nov 21, 2005 9:38 pm
by mith
I got the impression that HCl is created from proton pumps. I was doing my Russian history homework yesterday and I read about Rasputin and how he survived cyanide(incredible story, he survived like 3 assasination attempts). Anyway he had a disease that inhibits production of HCl.

http://en.wikipedia.org/wiki/Achlorhydria

No, it can't come from salt

Posted: Tue Nov 22, 2005 3:14 am
by burningredphoenix
It can't come from salt, The ion concentration would increase, however, the voltage difference would just rebond Cl to Na .

Posted: Tue Nov 22, 2005 4:41 pm
by Poison
So what is NaCl used for in your body?

Posted: Tue Nov 22, 2005 6:27 pm
by MrMistery
NaCl is a soruce of minerals, nothing more. Na and Cl are some of the most important minerals in the body. But the concentration is a fixed point(homeostazy) so eating more NaCl won't help you have more minerals in the body.
Now, Dave is right. HCl is not present in the cells of the stomach(i think the reason is obvious) so cells excrete K+ and Cl- separatly into the lumen by active transporters, and then they combine to form HCl, which is so important for the digestion process

Posted: Wed Nov 23, 2005 12:29 pm
by victor
MrMistery wrote:so cells excrete K+ and Cl- separatly into the lumen by active transporters, and then they combine to form HCl, which is so important for the digestion process


K+ and Cl- will form KCl....where's the H+ needed to form HCl ?

Posted: Wed Nov 23, 2005 6:39 pm
by MrMistery
I wrote K+ instead of H+. You want the real process? Fine!
Downloading from IBO training memory:
Co2 enters the parietal cell according to concentration gradient. There, the enzyme carbonic anhidrase is present. It catalises the reaction:
CO2 + H2O--> HCO3- + H+
H+ is excreted into the lumen through a pump identical to the one plants use to create H+ gradients
Now, Cl- enters the cell through an antiport with HCO3-, so the cell solves 2 problems: gets rid of HCO3- and gets the Cl- inside the cell. Then Cl- is excreted into the lumen through an ion channel according to the Gibbs-Donnan equilibrium. This channel is only present in the part of the cell facing the lumen.

Any questions? ;)

Posted: Thu Nov 24, 2005 12:10 pm
by Mjhavok
mithrilhack wrote:I got the impression that HCl is created from proton pumps. I was doing my Russian history homework yesterday and I read about Rasputin and how he survived cyanide(incredible story, he survived like 3 assasination attempts). Anyway he had a disease that inhibits production of HCl.

http://en.wikipedia.org/wiki/Achlorhydria



That is quite interesting

Posted: Thu Nov 24, 2005 4:53 pm
by Poison
MrMistery wrote:
Any questions? ;)


:shock: Nope

Posted: Thu Nov 24, 2005 6:32 pm
by MrMistery
LOL... Don't be afraid to ask Ozge... :)
By the way, a cool thing to know is that specific inhbitors for the H+ pump are used in treating stomach ulcer. I don't really know what they are called, but i don't think anyone really cares so...

Posted: Tue Nov 29, 2005 11:40 pm
by Terry K.
Doesn't nexium have those inhibitors, or is my memory for TV fading away as I speak?