DNA markers

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

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DNA markers

Post by mercy » Thu Feb 22, 2007 4:15 am

hi again,
we were discussing how to detect a gene of a recessive disease if we only have a family history or pedigree of three generation, how would you work it out?

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Post by MrMistery » Thu Feb 22, 2007 12:37 pm

when two normal people have a sick child, they were both heterozygous for the desease. Other than that i can not tell you anything without actually seeing the pedigree
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Post by Vagabond » Thu Feb 22, 2007 1:04 pm

Yep I agree with MrMistery not much more can be added with the little information that you have provided. Perhaps post the family tree marking normals and effected individuals. Use open squares for normal males and open circles for normal females and closed for effected individuals. Does this disease mainly affect males (i.e. X-linked??)

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