Researchers conduct to verify anti-aging proteins

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Researchers conduct to verify anti-aging proteins

Post by biokit » Wed Aug 24, 2016 8:30 am

A research team from Harvard University said they found GDF11 protein could explain the beneficial effects of the young blood. They used to report that when animals get old, GDF11 concentration in blood will drop, while injecting GDF11 to old mice would partially reverse age-related thickening of the heart. Two studies of Wagers and his colleagues about that GDF11 can improve muscle and brain function of rodents were published in the journal Science. There are many GDF11 recombinant proteins in the market.

However, their results were questioned. The research team led by muscle disease specialist David Glass at Novartis Institutes for BioMedical Research (NIBR) reported that the antibody used by Harvard University team to test the content of GDF11 can also be used to test myostatin (also called GDF8 which has 89% similarity to GDF11). This protein can hinder muscle growth. Novartis team used different methods of analysis and concluded that with the aging of rat and human, the GDF11 content in blood actually increases. In their laboratory, GDF11 injection will inhibit muscle regeneration of young mice.

Faced this query, the team of Wagers and Lee recently published again to fight back. They claimed that the method used by Novartis team to detect GDF11 and GDF8 was flawed itself. They found that the main protein which passed antibody detection was immunoglobulin, and the protein concentration in blood will increase with age. When testing mice with lack of immunoglobulin genes, the test result of GDF11 / 8 active form was negative, so the method of Novartis is not accurate. The study was published in the journal Circulation Research.

Back to the latest papers of Wagers and his partners, they found that daily injections of GDF11 can reduce the myocardium old and newborn mice. But this time they also found another phenomenon: the weight of mice would also reduce. "We currently know very little about this, but we are conducting research," Wagers said. Also, similar to other hormones, the beneficial effects of GDF11 may have therapeutic window - excessive doses may cause side effects.

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Re: Researchers conduct to verify anti-aging proteins

Post by Vmedvil » Tue Aug 15, 2017 8:19 am

Well, generally speaking that is true of most proteins over time the DNA of the cells starts to gain mutations which silence the gene that generates the proteins needed by the body. The lower concentration of that protein just shows the amount of damaged gene sequences that were generated by DNA repair failures. Of course, injecting the mouse with that protein will cause the job that the protein is supposed to do to be done again thus reversing the effects of aging on the mice's heart tissues caused from a lack of that job being done. Just as when you have a lower insulin concentration in the body which makes the body unable to process Sugars you replace the insulin not being produced by the body with injected insulin allowing the job of the insulin being to process sugar to be done again. The concept is the same, I think that these scientists are right on about this from this example.

As for the reduced weight of the mice that is caused by the increased protein amount using more energy to power these excess proteins in the mice, too much of anything can be bad, there is always a balance needed in the body of any organic creature.
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