Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.
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Bcl-2 family proteins, which include pro- and antiapoptotic members, positively or negatively regulate MOM permeabilization, i.e. a barrier to apoptosis induction. Over-expression of pro-survival members is associated with tumor progression and may be responsible for drug resistance, while pro-apoptotic members may promote sustained cell death during both acute injuries and chronic degenerative disorders. Detailed understanding of the precise biochemical mechanisms by which Bcl-2 family members control mitochondrial apoptosis is therefore of considerable therapeutic interest. (More information about the lab “POROS” on Labslink.com)
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