Developmental Biology-I need help

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Developmental Biology-I need help

Post by skyblue » Fri Nov 07, 2008 4:25 pm

Can someone please try to explain how netrin receptors receive and process guidance signals for both attractive and repulsive responses with reference to netrins as morphogens and molecular components downstream of netrin receptors.

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Re: Developmental Biology-I need help

Post by jonmoulton » Fri Nov 07, 2008 7:03 pm

Here are a few netrin-related references. You can see the abstracts by entering the titles on the NCBI front page and selecting search: PubMed.

Katow H. Spatio-temporal expression of a Netrin homolog in the sea urchin Hemicentrotus pulcherrimus (HpNetrin) during serotonergic axon extension. Int J Dev Biol. 2008;52(8):1077-88.

Wilson NH, Key B. Neogenin interacts with RGMa and netrin-1 to guide axons within the embryonic vertebrate forebrain. Dev Biol. 2006 Aug 15;296(2):485-98. Epub 2006 Jun 15.

Navankasattusas S, Whitehead KJ, Suli A, Sorensen LK, Lim AH, Zhao J, Park KW, Wythe JD, Thomas KR, Chien CB, Li DY. The netrin receptor UNC5B promotes angiogenesis in specific vascular beds. Development. 2008 Feb;135(4):659-67.

Leung KM, van Horck FP, Lin AC, Allison R, Standart N, Holt CE. Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1. Nat Neurosci. 2006 Oct;9(10):1247-56. Epub 2006 Sep 17.

Larrivee B, Freitas C, Trombe M, Lv X, Delafarge B, Yuan L, Bouvree K, Breant C, Del Toro R, Brechot N, Germain S, Bono F, Dol F, Claes F, Fischer C, Autiero M, Thomas JL, Carmeliet P, Tessier-Lavigne M, Eichmann A. Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev. 2007 Oct 1;21(19):2433-47.

Hotta K, Yamada S, Ueno N, Satoh N, Takahashi H. Brachyury-downstream notochord genes and convergent extension in Ciona intestinalis embryos. Dev Growth Differ. 2007 Jun;49(5):373-82.

Suli A, Mortimer N, Shepherd I, Chien CB. Netrin/DCC signaling controls contralateral dendrites of octavolateralis efferent neurons. J Neurosci. 2006 Dec 20;26(51):13328-37.

Wilson BD, Ii M, Park KW, Suli A, Sorensen LK, Larrieu-Lahargue F, Urness LD, Suh W, Asai J, Kock GA, Thorne T, Silver M, Thomas KR, Chien CB, Losordo DW, Li DY. Netrins promote developmental and therapeutic angiogenesis. Science. 2006 Aug 4;313(5787):640-4. Epub 2006 Jun 29.

Eichmann A, Makinen T, Alitalo K. Neural guidance molecules regulate vascular remodeling and vessel navigation. Genes Dev. 2005 May 1;19(9):1013-21. Review.

Shim S, Goh EL, Ge S, Sailor K, Yuan JP, Roderick HL, Bootman MD, Worley PF, Song H, Ming GL. XTRPC1-dependent chemotropic guidance of neuronal growth cones. Nat Neurosci. 2005 Jun;8(6):730-5. Epub 2005 May 8.

Xie Y, Ding YQ, Hong Y, Feng Z, Navarre S, Xi CX, Zhu XJ, Wang CL, Ackerman SL, Kozlowski D, Mei L, Xiong WC. Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth. Nat Cell Biol. 2005 Nov;7(11):1124-32.

Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Breant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004 Nov 11;432(7014):179-86. Epub 2004 Oct 27.

Wang GX, Poo MM. Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones. Nature. 2005 Apr 14;434(7035):898-904. Epub 2005 Mar 9.

Mawdsley DJ, Cooper HM, Hogan BM, Cody SH, Lieschke GJ, Heath JK. The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish. Dev Biol. 2004 May 1;269(1):302-15.

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