Search found 81 matches

by claudepa
Fri Sep 22, 2017 3:25 pm
Forum: Cell Biology
Topic: Mutations P53
Replies: 1
Views: 3594

Do you mean why is there a high rate of genome mutations when P53 is itself mutated ?
by claudepa
Wed Jun 14, 2017 4:23 pm
Forum: Genetics
Topic: Does evolution act on Societies?
Replies: 3
Views: 7221

Re: Does evolution act on Societies?

I do not know if science would be able to answer this question. Newspapers regularly give a list of countries where life is supposed to be the better with a ranking from the best to the worst. That is very subjective. Researchers could try, if it is ethically allowed, to correlate this subjective ra...
by claudepa
Tue Jun 13, 2017 12:12 pm
Forum: Genetics
Topic: Does evolution act on Societies?
Replies: 3
Views: 7221

Re: Does evolution act on Societies?

I am not a specialist of evolution nor a genetician but a biologist. So my answer is more based on my general knowledge of biology.A field of genetics is called genetics of populations. When you say that evolution affects the genes of the individual, yes and no. Because the selected genes of one ind...
by claudepa
Thu Jun 01, 2017 1:21 pm
Forum: General Discussion
Topic: Need to Gather Information on Cancer
Replies: 1
Views: 2598

Re: Need to Gather Information on Cancer

Hi Jessica. this is a little bit practical R an D in a patient. May be it could be useful for your assignement. my wife had in april 2016 a very agressive metastatic relapse of a triple negative breast cancer (TNBC) treated 2 years and 6 months before as a 8 mm breast tumor stade 1. The 2016 first l...
by claudepa
Mon May 22, 2017 3:48 pm
Forum: Evolution
Topic: Can anyone find flaws in this mathematical proof?
Replies: 4
Views: 8623

Re: Can anyone find flaws in this mathematical proof?

Do not be impressed by mathematical equations. I was trained in mathematics and after I became a biologist. In the begining of my work as a biology researcher I tried to make mathematical models explaining my biological results. And then I found that biology is far too complicated to be mathematical...
by claudepa
Thu Apr 27, 2017 1:17 pm
Forum: Molecular Biology
Topic: What is the size of an antibody
Replies: 17
Views: 51696

Re: What is the size of an antibody

10 nm length for an antibody means that it is indeed the size of small nanoparticles. I am working in therapeutic research with non biodegradable 7 nm nanoparticles. We look for this size because it can allow elimination by kidney. However it is not easy because they have a tendency to agregate and ...
by claudepa
Tue Apr 18, 2017 10:05 am
Forum: Molecular Biology
Topic: bohr effect
Replies: 1
Views: 3776

I do not know the Bohr effect but it seems that you have an equilibrium between HBO2 and H+ on one side and HBH+ and 02 on the other. There should be one pKa for this equilibrium.
by claudepa
Tue Apr 18, 2017 9:49 am
Forum: Cell Biology
Topic: Bacterial DNA replication (Circular)
Replies: 1
Views: 3508

Re: Bacterial DNA replication (Circular)

DNA pol is a complex of many proteins. Some of them: DNA A, DNA B, pol1, pol2, pol3. primase. pol1 was the first to be discovered by Arthur Kornberg. It is why it is called 1. But in fact the one which is synthetizing DNA at the replication forks is pol3. probably pol1 was more abondant and it is wh...
by claudepa
Tue Apr 18, 2017 9:35 am
Forum: Cell Biology
Topic: Nucleoside Triphosphate Binding to complimentary Nucleotide
Replies: 1
Views: 3079

Re: Nucleoside Triphosphate Binding to complimentary Nucleot

If you are speaking of DNA synthesis, binding between complementary nucléotides (Watson Crick rules) is done through hydrogen bonding, 2 bonds for AT and 3 bonds for GC. Polymerisation takes place within the new strand and is not related to the complementary bases of the old strand. For bacterial DN...
by claudepa
Sun Apr 02, 2017 1:54 pm
Forum: General Discussion
Topic: How do I calculate the number of thiol groups?
Replies: 1
Views: 3176

Re: How do I calculate the number of thiol groups?

This is the way I would make the calculation. However I find something wrong in the numerical application. Is your eps OK ? I do not see why using V. If I understand well the data your equation starts from the beer lambert equation: OD =eps x l x C where l is the length of the cuvette and C the conc...
by claudepa
Fri Mar 31, 2017 2:56 pm
Forum: Molecular Biology
Topic: Stacking interactions in DNA - help needed
Replies: 3
Views: 4880

Re: Stacking interactions in DNA - help needed

I said you are already a specialist because you took time to look your point on stacking in books and articles and you are very motivated to find the answer. Do not believe that necessarily some specialized reseracher knows the answer to your question. May be yes may be no. When I was doing my phD I...
by claudepa
Thu Mar 30, 2017 10:44 am
Forum: Molecular Biology
Topic: Stacking interactions in DNA - help needed
Replies: 3
Views: 4880

Re: Stacking interactions in DNA - help needed

you are obviously already a specialist of this field. You could see also DNA intercalating agents. Some have a very high affinity for DNA. They intercalate between base pairs and their high affinity is due to stacking forces. They are positively charged, otherwise they could not have access to DNA. ...