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<p>..................................................</p> <p><a></a><br><strong>Table 1.</strong> Comparison of current methodologies for use in high-throughput epigenome profiling </p> <table><tbody><tr><td> <table><tbody><tr><td> </td> <td>Pretreatment of material</td> <td>Detection</td> <td>Prior sequence selection</td> <td>Global (G)/individual (I) CpG mapping</td> <td>Whole genome coverage</td> <td>Quantifiable</td> </tr><tr><td><hr></td> </tr><tr><td>DNA methylation maps</td> <td>Bisulphite treatment of DNA</td> <td>PCR and sequencing</td> <td>Y</td> <td>I</td> <td>N</td> <td>N</td> </tr><tr><td> </td> <td> </td> <td>Pyrosequencing/MALDI-MS</td> <td>Y</td> <td>I</td> <td>N</td> <td>Y</td> </tr><tr><td> </td> <td> </td> <td>Q-PCR</td> <td>Y</td> <td>I</td> <td>N</td> <td>Y</td> </tr><tr><td> </td> <td> </td> <td>Hybridization to CpG and TpG oligo microarrays</td> <td>Y</td> <td>I</td> <td>N</td> <td>Y</td> </tr><tr><td> </td> <td>Restriction enzyme techniques</td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr><tr><td> </td> <td> RLGS</td> <td>Cloning into libraries and sequencing</td> <td>N</td> <td>G</td> <td>Y</td> <td>N</td> </tr><tr><td> </td> <td> McrBC/Meth sensitive RE</td> <td>Hybridization to genomic microarrays</td> <td>N</td> <td>G</td> <td>M</td> <td>Y</td> </tr><tr><td> </td> <td> MS-RDA</td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr><tr><td> </td> <td>ChIP with antibodies to MBDs</td> <td>Cloning into libraries and sequencing</td> <td>N</td> <td>G</td> <td>Y</td> <td>N</td> </tr><tr><td> </td> <td> </td> <td>Hybridization to genomic microarrays</td> <td>N</td> <td>G</td> <td>M</td> <td>Y</td> </tr><tr><td>Histone modification maps</td> <td>ChIP</td> <td>Hybridization to genomic/amplicon/oligo microarrays (ChIP-chip)</td> <td>N</td> <td> </td> <td>M</td> <td> </td> </tr><tr><td> </td> <td> </td> <td>Cloning into libraries and sequencing</td> <td>N</td> <td> </td> <td>Y</td> <td> </td> </tr><tr><td> </td> <td> </td> <td>ChIP-BS</td> <td>Y</td> <td> </td> <td>N</td> <td> </td> </tr><tr><td>Physical chromatin structure</td> <td>Chromatin fractionation</td> <td>Hybridization to genomic/amplicon/oligo microarrays</td> <td>N</td> <td> </td> <td>M</td> <td> </td> </tr></tbody></table></td> </tr></tbody></table><p>Y, yes; N, no; M, maybe depending on the coverage of the microarray. </p> <div>..................................................</div> <p> </p> <p><em>Source: Human Molecular Genetics 2005 14(suppl_1):R3-R10</em><br></p>
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