Medicinal products susceptible to “dose dumping” should be fully tested
Controlled release pills and capsules that show a tendency in the standard laboratory test toward “dose dumping” should be withheld from the market until proven safe with testing in people

Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor suppressor syndrome, characterized by hamartomatous growths in the brain, skin, kidneys, lungs, and heart, which lead to significant morbidity.

The mode of action of dimeticone 4% lotion against head lice, Pediculus capitis
This work raises doubts that lice treated using dimeticone preparations die from anoxia despite blockage of the outer respiratory tract because movements can be observed for hours after exposure.

Effects of streptozotocin-induced diabetes on the pharmacology of rat conduit and resistance intrapulmonary arteries
The aim of this study was to determine how the pharmacological reactivity of intrapulmonary arteries is altered in a rat model of diabetes.

Long-lasting Nerve Block Could Revolutionize Pain Management
Researchers have developed a slow-release anesthetic drug-delivery system that could potentially revolutionize treatment of pain during and after surgery, and may also have a large impact on chronic pain management.

Potentially Safer General Anesthetic Developed
A team of Massachusetts General Hospital (MGH) physicians has developed a new general anesthetic that may be safer for critically ill patients

Women At Risk Of Gaining Excessive Weight With Injectable Birth Control Identified
Researchers at the University of Texas Medical Branch at Galveston have identified women who are likely to gain weight while using depot medroxyprogesterone acetate, more commonly known as Depo-Provera or the birth control shot.

Flu Pandemic Drugs: Using Small Stockpile Of Secondary Antiviral Drugs Could Extend Effectiveness
In a global influenza pandemic, small stockpiles of a secondary flu medication – if used early in local outbreaks – could extend the effectiveness of primary drug stockpiles

Fighting Drug-resistant Flu Viruses
Scientists in Japan are reporting a first-of-its kind discovery that could foster a new genre of antivirals that sidestep resistance problems...

Researchers Warn: 'Antivirals Might Be Wasted On The Elderly'
A model of influenza transmission and treatment suggests that, if the current swine flu pandemic behaves like the 1918 flu, antiviral treatment should be reserved for the young.

Common Allergy Drug Reduces Obesity And Diabetes In Mice
Crack open the latest medical textbook to the chapter on type 2, or adult-onset, diabetes, and you'll be hard pressed to find the term "immunology" anywhere...

Potential new drugs: 970 million and still counting
Like astronomers counting stars in the familiar universe of outer space, chemists in Switzerland are reporting the latest results of a survey of chemical space — the so-called chemical universe where tomorrow’s miracle drugs may reside.

Toward new drugs that turn genes on and off
Scientists in Michigan and California are reporting an advance toward development of a new generation of drugs that treat disease by orchestrating how genes in the body produce proteins involved in arthritis, cancer and a range of other disorders.

First broad spectrum anti-microbial paint to kill “superbugs”
Scientists in South Dakota are reporting development of the first broad-spectrum antimicrobial paint, a material that can simultaneously kill not just disease-causing bacteria but mold, fungi, and viruses.

Vaccine for the Infected? New TB Vaccine Clears Important Hurdle
An urgently needed new tuberculosis vaccine cleared a vital step in testing...

While Focusing on Heart Disease Interventions, Researchers Discover New Tactic Against Fatal Muscular Dystrophy
Based on a striking similarity between heart disease and Duchenne muscular dystrophy, researchers have discovered that a new class of experimental drugs for heart failure may also help treat the fatal muscular disorder.

Preparative HPLC
Preparative HPLC as a versatile, robust and widely used technique for isolation and purification. Its main application is for samples where more traditional open column chromatography failed to produce adequate resolution.

Anti-Fungal Drug Offers Great Benefits to Some with Severe Asthma
Some patients with severe asthma who also have allergic sensitivity to certain fungi enjoy great improvements in their quality of life and on other measures after taking an antifungal drug

Key advance toward treatment for most common adult form of muscular dystrophy
Scientists in New York are reporting a critical first step toward development of a long-sought drug to treat myotonic muscular dystrophy (MMD)

A new way to remove unwanted heparin from blood
Scientists in Poland are reporting development of a potential new way to quickly remove the anticoagulant heparin from patients’ blood in order to avoid unwanted side effects that can happen with the current use of that blood thinner.