Aquaglyceroporin AQP9: Solute permeation and metabolic control of expression in liver
Aquaglyceroporins form the subset of the aquaporin water channel family that is permeable to glycerol and certain small, uncharged solutes.

Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo
Available in vitro and in vivo methods for verifying protein substrates for posttranslational modifications via farnesylation or geranylgeranylation

Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain
These findings contribute to define the growing group of human polyserine proteases composed at present by three different proteins.

The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site
The present data show that the splicing factor SF3b1 is a substrate of the protein kinase DYRK1A and suggest that DYRK1A may be involved in the regulation of pre mRNA-splicing.

Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels
In an effort to investigate how loss of deneddylation affects SCF activity, the authors conditionally silenced the catalytic subunit of CSN in mammalian cells.

Discovering structural motifs using a structural alphabet: Application to magnesium-binding sites
The structural motif discovery method presented herein is general and can be applied to any set of proteins with known 3D structures.

New protein is essential for lung development
A recently discovered protein appears essential for lung development.

Misbehaving Molecules In ALS; 3-dimensional Pictures Of ALS Mutant Proteins Support Two Major Theories About How The Disease Is Caused
A new study reveals for the first time how gene mutations lead to the inherited form of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease.

UNC scientists solve mystery of how largest cellular motor protein powers movement
Scientists now understand how an important protein converts chemical energy to mechanical force

Mechanism For Neurodenegerative Diseases Linked To Transport Proteins
Hampering the transport of proteins within cells may underlie several adult-onset neurodegenerative diseases

Mutations In Transporter Protein Shed Light On Neurodegenerative Disorders
Researchers at Stanford University have made new discoveries that shed light on two inherited neurodegenerative disorders that are caused by inability of the body to transport sialic acid out of cellular compartments.

The loss of a protein favors lung tumor growth
The researcher Zafira Castaño has discovered that the loss of a protein in the early phases of lung cancer favors tumor growth.

Redesigned protein accelerates blood clotting
Study holds hope for next generation hemophilia treatment

Scientists discover proteins involved in spread of HIV-1 infection
An international team of researchers has identified a family of proteins that are involved in HIV-1 budding from host cells, and are therefore likely to be essential for the spread of the virus.

Suspect protein found to play protective role in chronic lung disease
A cell surface protein regarded as a potential troublemaker in the lungs plays an unexpected protective role mitigating the damage caused by chronic pulmonary diseases such as asthma.

Researchers Identify A Protein That Could Banish Allergies
News: The suffering of millions of people with allergies could one day be eased thanks to new research from UK investigators.

Natural Protein Helps Prevent Cancers From Spreading To Other Organs
News: A small protein released by cancer cells can inhibit the growth of secondary tumors in mice and could be used to design new types of anti-cancer drugs, according to Canadian researchers.

A surprising pair of proteins help make healthy eggs
News: Human eggs rely on handmaidens. Called granulosa cells, they surround eggs and deliver nutrients and hormones. Without granulosa cells, eggs cannot mature and be successfully fertilized...

Mutant proteins may be key to defeat chemical warfare
News: Enzymes - proteins commonly used to speed up chemical reactions - can render chemical warfare agents and insecticides harmless by breaking them apart.

Research Answers Key Question In Biochemistry: How Proteins Fold Into 3-D Structures
News: University of Toronto scientists are helping to answer one of the most important questions in biochemistry, one that has implications for treating neurodegenerative diseases: how do proteins fold into their three-dimensional structures?