Post-transcriptional nucleotide modification and alternative folding of RNA
Alternative foldings are an inherent property of RNA and a ubiquitous problem in scientific investigations.

Reverse Polarization in Amino acid and Nucleotide Substitution Patterns Between Human–Mouse Orthologs of Two Compositional Extrema
Genome-wide analysis of sequence divergence patterns in 12 024 human–mouse orthologous pairs reveals

New way to label nucleic acids could lead to new therapies
Nucleic acids embrace many more kinds of molecules than just giant strands of DNA and RNA, and several forms have shown promise for therapy.

Renegade RNA -- Clues to cancer and normal growth
Researchers at Johns Hopkins have discovered that a tiny piece of genetic code apparently goes where no bit of it has gone before, and it gets there under its own internal code.

Molecule crucial for processing non-coding RNA identified
Long-standing scientific question resolved

RNA splicing occurs in nerve-cell dendrites
Researchers at the University of Pennsylvania School of Medicine have discovered that nerve-cell dendrites have the capacity to splice messenger RNA

CSHL shows correcting rna splicing may help treat spinal muscular atrophy
RNA splicing antisense technology studied at Cold Spring Harbor Laboratory (CSHL) effectively corrected an mRNA splicing defect found in spinal muscular atrophy (SMA) patients

A brave new "old world" of RNA
A new function for RNA, which further elucidates how genes are expressed and regulated, is described on the 25th of November issue of the journal Nature.

Towards a unified model of transcription termination
A new, unified model for transcription termination by RNA Poymerase II...

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription
The distribution of the four nucleotides along the DNA sequence encodes the genetic information in living systems.

Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
Nucleic acid ligands (referred to as aptamers) are short DNA or RNA fragments that can bind to target antigens with high specificity and affinity

A real time look at interactions between RNA and proteins
For the first time, researchers can now peer inside intact cells to not only identify RNA-binding proteins

Dinosaur DNA? New Patent Covers Degraded DNA recovery
The US Patent Office issued Patent # 6,872,552, "A Method of Reconstituting Nucleic Acid Molecules" today to Burt D. Ensley, Ph.D, Chairman of MatrixDesign, and CEO of DermaPlus, Inc

Synthesis and Use of Modified Peptide Nucleic Acids for Visual Detection of DNA
Modification of peptide nucleic acids (PNAs) by the incorporation of trans-1,2-diaminocyclopentane into the PNA provides for more highly sensitive and selective detection of DNA and RNA sequences.

Nucleic Acid-Amplification Testing Further Safeguards Nation's Blood Supply, NHLBI Study Shows
State-of-the-art testing systems to screen donated blood have improved the safety of the nation's blood supply by preventing the transmission of potentially deadly viruses

Nucleotide Excision Repair and Cancer
ABSTRACT: Enviromental or endogenous DNA damages of genomic DNA are either repaired by DNA repair mechanisms or lead apoptosis in living organisms.

Human MicroRNA Targets
Their analysis suggests that miRNA genes, which are about 1% of all human genes, regulate protein production for 10% or more of all human genes.

MicroRNA: Biogenetic and Functional Mechanisms and Involvements in Cell Differentiation and Cancer
In this review, recent remarkable advances in the miRNA biogenetic and functional mechanisms and the involvements of miRNAs in cell differentiation, especially in hematopoietic lineages, and cancer were discussed.

On the Biological Significance of DNA Methylation
This chapter presents a personal account of the work on DNA methylation in viral and mammalian systems performed in the author's laboratory in the course of the past thirty years.

Mutation of exposed hydrophobic amino acids to arginine to increase protein stability
The study aimed to test the increase in stability of proteins by reducing the area of water-accessible hydrophobic surface...