Coenzyme Q Shortens Life Span Of Worms Substantially, UCLA Chemists Report
A popular dietary supplement, Coenzyme Q, accelerates aging and death in a microscopic worm studied by UCLA biochemists.

UC Riverside Biochemists Develop Technology To Increase Vitamin C In Plants
Biochemist have developed technology that increases the amount of vitamin C in plants, including grains, by increasing the amount of the enzyme that is responsible for recycling vitamin C.

Striking The Right Balance Between Excitation And Inhibition
Neurons in the brain and spinal cord come in two flavors, excitatory neurons that transmit and amplify signals, and inhibitory neurons that inhibit and refine those signals

Nuclear Receptor Minireview Series
The nuclear receptor superfamily describes a related but diverse array of transcription factors, which include nuclear hormone receptors (NHRs)1 and orphan nuclear receptors.

Signaling the Unfolded Protein Response from the Endoplasmic Reticulum
The authors discussed the basic components of the UPR pathways, the physiological roles of the UPR signaling, and the future direction of the field.

Ketone Bodies Stimulate Chaperone-mediated Autophagy
Study shows that treatment of cells with ketone bodies increased the proteolysis of long-lived proteins under conditions in which most proteolysis is due to Chaperone-mediated autophagy.

A New Class of Peroxisome Proliferator-activated Receptor Agonists with a Novel Binding Epitope Shows Antidiabetic Effects*
In here the authors described a new class of PPAR agonists, the 5-substituted 2-benzoylaminobenzoic acids (2-BABAs)...

The channel architecture of aquaporin 0 at a 2.2-Å resolution
In this study the x-ray structure of bovine aquaporin 0 (AQP0) was determined to a resolution of 2.2 Å.

Determination of the substrate-docking site of protein tyrosine kinase C-terminal Src kinase
In this study, the authors determined a substrate-docking site on Csk that is critical for its ability to bind to, phosphorylate, and regulate SFKs but is not important for the general kinase activity.

Sugar recognition by human galactokinase
Since only studies on human enzyme are likely to be of value in the design of therapeutically useful inhibitors for galactosemia, this study was carried out using recombinant human galactokinase...

Cholesterol-regulating Protein Maintains Fat-storage, Fat-burning Balance
News: A protein that regulates cholesterol levels in the body also is responsible for maintaining a healthy balance between fat storage and fat burning, according to a UT Southwestern Medical Center study that may lead to new drug targets in the fight aga

'Bad' enzymes may wear white hats after stroke
News: Enzymes that can harm the brain immediately after a stroke may actually be beneficial days later, according to new research. Insights from the study could change the way stroke is treated...

Inhibition Of Iron-metabolizing Enzyme Reduces Tumor Growth
News: An inhibition of heme oxygenase-1, an enzyme involved in iron metabolism, reduced Kaposi sarcoma tumor growth. This discovery could result in the production of new drugs to treat this and other viral cancers.

UT Southwestern team isolates key protein in transforming excess glucose into fat
News: A biochemistry team has identified a glucose-sensitive protein that translates excessively high-carbohydrate intake into body fat, especially when combined with a sedentary lifestyle.

Folate and DNA methylation during in utero development and aging
This article describes the relationship between folic acid and DNA methylation, and the association between DNA methylation during in utero development and aging.

Researchers reveal basis for debilitating hereditary disease
A research team led by scientists at The University of Texas Medical School at Houston has determined the structure of an enzyme that when defective causes an inherited disease that afflicts sufferers with severe abdominal pain, psychiatric symptoms, skin

New discovery blurs distinction between human cells and those of bacteria
Cells of prokaryotes have been viewed as very primitive yet UCLA biochemists found the first structural details of mysterious objects called microcompartments to be present in a variety of bacteria. Their findings blur the distinction between eukaryotic c

Study reveals biochemical signature of cocaine craving in humans
Using sophisticated brain-imaging techniques at the U.S. Department of Energy's Brookhaven National Laboratory, scientists from the National Institute on Drug Abuse (NIDA), Brookhaven Lab, and the University of Pennsylvania have uncovered the brain chemis

New clues to biochemistry of anti-aging
University of Wisconsin-Madison researchers have found that sirtuins, a family of enzymes linked to a longer life span and healthier aging in humans, may orchestrate the activity of other enzymes involved in metabolic processes in the body.