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Signal transduction

Signal transduction

The cascade of processes by which an extracellular signal (typically a hormone or neurotransmitter) interacts with a receptor at the cell surface, causing a change in the level of a second messenger (for example calcium or cyclic AMP) and ultimately effects a change in the cells functioning (for example: triggering glucose uptake or initiating cell division). Can also be applied to sensory signal transduction, for example of light at photoreceptors.


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Re: cAMP as second messenger in GPCR signal transduction

Thank you very much for your help.

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by hplc
Mon Feb 16, 2009 7:09 pm
 
Forum: Cell Biology
Topic: cAMP as second messenger in GPCR signal transduction
Replies: 2
Views: 714

cAMP as second messenger in GPCR signal transduction

Hello. I'm currently reading about the signal transduction from G protein-coupled receptors in relation to the cAMP second messenger. But after this ...

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by hplc
Sun Feb 15, 2009 12:31 pm
 
Forum: Cell Biology
Topic: cAMP as second messenger in GPCR signal transduction
Replies: 2
Views: 714

Re: proteins found in the cell membrane.

... active, aquaporins etc) 2. Enzyme proteins (Integral and peripheral) 3. Signal transduction proteins (hormone reception, coat proteins?) 4. Cell recognition (Here's your ...

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by keenangp
Thu Dec 18, 2008 4:54 am
 
Forum: Cell Biology
Topic: proteins found in the cell membrane.
Replies: 3
Views: 1363

How does a mutated gene affect Tyrosine Kinase?

I believe you are correct, in both instances the signal transduction would be inhibited. 1) the receptor is not able to bind the ligand properly, therefore ...

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by HELISA
Sat Nov 22, 2008 9:44 pm
 
Forum: Cell Biology
Topic: How does a mutated gene affect Tyrosine Kinase?
Replies: 1
Views: 515

Re: 5 questions without answers...!

... to GFP. After transfection, where would I expect to see fluorescent signal first appearing? Is this based on a ribosomal location? Membrane? ... the soluble form of VEGFR-1 in the extracellular spaces affect signal transduction? I am only aware of intracellular mechanisms. VEGF that is bound ...

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by snowcapk
Thu Aug 07, 2008 5:21 am
 
Forum: Molecular Biology
Topic: 5 questions without answers...!
Replies: 2
Views: 749
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