Regeneration

I don't have full access to the article right now, so what does it mean by: . . . using a strategy of re-expressing key developmental regulators in vivo, we identify a specific combination of three transcription factors (Ngn3 (also known as Neurog3) Pdx1 and Mafa) that reprograms differentiated panc...

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... distinction between "transdifferentiation" and the "dedifferentiation and then differentiation" that occurs during epimorphic regeneration? Is it just the process of reployment of developmental programming during the latter, while the former has a different process of reprogramming? ...

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The more we tinker around with stem cells, the closer we will get to unlocking the mysteries. I am not a big fan of letting Mother Nature do all the tinkering around: evolutionary pressure. Though she gets to make the big evolutionary ones because she can do what she wants and has no rules to follow...

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... is a good word to describe the same I tried with "advanced". Anyways, I'm not too sure there's much evolutionary pressure towards regeneration in humans, quite the contrary: we can probably make excellent artificial limbs long before evolution has time to do anything about it :) ...

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... status. But if the dna "blueprints" are still there, we should be able to create an environment (albeit complex) to facilitate regeneration. The cytokine and hormone environment has been brought up in the literature to be conducive to fibrosis. I believe that it is cytokines, ...

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