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NADPH dehydrogenase (quinone)

A flavoprotein similar to nADH dehydrogenase (quinone), but oxidizing nADPH.

Synonym: dT-diaphorase, menadione reductase, phylloquinone reductase, quinone reductase. NAD(p)h dehydrogenase (quinone)

(Science: enzyme) A flavoprotein that reversibly catalyses the oxidation of nADH or nADPH by various quinones and oxidation-reduction dyes. Since the enzyme is a part of the mitochondrial respiratory chain, defects or deficiencies of this enzyme are an important cause of neurological diseases such as parkinsonism. It may have a protective effect against cancer caused by quinones or their metabolic precursors. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.

Chemical name: NAD(P)H:(quinone-acceptor) oxidoreductase

Registry number: EC 1.6.99.2