Moieties

Conjugation of Morpholino oligos with endosomal escape moieties is bringing effective antisense techniques to rodent research. Such conjugates will likely debut soon as therapeutics. This is an open-access review of two delivery-enabled forms of Morpholinos. ...

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... peptide-Morpholino conjugates have shown that the oligos enter cells by endocytosis and then escape from the endosome. In some way, the peptide moieties render the endosomal membrane permeable. This may be due to the combined electrostatic attraction and hydrogen-bonding of the guanidiniums ...

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... the same. However, the way to determine the location of the antibodies differs. Immunofluorescent methods use antibodies labeled with fluorescent moieties (fluorochromes). Usually these are conjugated with a secondary antibody which is used to bind to a primary antibody bound to cellular antigen. ...

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... sugars like glucose or galactose or ribose etc. are the monomers while pectin or starch or O- or N-linked glycopeptide carbohydrate moieties are polymers. Lipids are a bit more problematic depending on how you consider them. Some lipids can be constructed from “acetates” but the ...

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... AND BIOLOGICAL SENSOR DEVICES HAVING ELECTROACTIVE POLYMER THIN FILMS ATTACHED TO MICROFABRICATED DEVICES AND POSSESSING IMMOBILIZED INDICATOR MOIETIES US Patent No. Inventor: Anthony Guiseppi-Elie US Patent Serial No. 08/318,494 Allowed on: August 8, 1996 Assignee: Anthony Guiseppi-Elie ELECTROACTIVE ...

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