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Dictionary » M » Missense mutation

Missense mutation

Definition

noun

A form of point mutation resulting in a codon that codes for a different amino acid, and thus, causes the synthesis of a protein with an altered amino acid sequence during translation.


Supplement

A missense mutation may lead to the synthesis of a protein that is nonfunctional. For instance in sicke-cell disease, the 20th nucleotide of the gene for the beta chain of hemoglobin on chromosome 11 is changed from the codon GAG to GTG so that when translated the 6th amino acid is now a valine in stead of glutamic acid.


Compare: nonsense mutation, silent mutation
See also: point mutation


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protein sequence

... in a way that inhibits/enhances function. Strictly speaking, benign missense mutation do exist. Of course if your professor told you otherwise, I'd stick with his/her story.

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by mith
Tue Dec 11, 2007 9:09 pm
 
Forum: Molecular Biology
Topic: protein sequence
Replies: 6
Views: 794

synonymous vs conservative missense mutation

Hi hiro. Synonymous (or silent) mutation is when there is substitution of 1 base for another. However this type causes ... acid e.g. If CAU is changed to CAC it does not matter as both encode histidine. Missense (or non-synonymous) mutations cause base substitution resulting in a codon ...

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by Katy_Bobbles
Sat Aug 25, 2007 4:50 pm
 
Forum: Genetics
Topic: synonymous vs conservative missense mutation
Replies: 6
Views: 2259

synonymous vs conservative missense mutation

i don't know the differences between these 2 mutation... look the same to me... and how do we know which mutation will be synonymous/ missense by looking at the change of codon?

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by hiro
Sat Aug 25, 2007 3:07 am
 
Forum: Genetics
Topic: synonymous vs conservative missense mutation
Replies: 6
Views: 2259

type of mutation

... or CHROMOSOME MUTATIONS according to the size of alteration. Gene mutations can be divided as: 1-) Lethal Mutations 2-)Conditional Mutations ... 1-) The substitution of one base pair for another a-)Silent Mutation b-)Missense mutation c-)Non sense mutation 2-)The addition or deletion of a ...

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by Seda
Sat Sep 17, 2005 12:28 am
 
Forum: Genetics
Topic: type of mutation
Replies: 4
Views: 2137

Radition harm.

Gamma rays have the highest penetration effect and it can cause a missense mutation or nonsense mutation to the chromosomes. so, because of these two mutations on the ...

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by victor
Fri Jul 01, 2005 11:41 am
 
Forum: General Discussion
Topic: Radition harm.
Replies: 8
Views: 1803
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