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Lethal mutation

Definition

noun

A type of mutation in which the effect(s) can result in the death or reduce significantly the expected longevity of an organism carrying the mutation.


Supplement

For instance, brachydactyly is a fatal when the genetic defect is expressed during infancy in homozygous recessive individuals.


Compare: nonlethal mutation


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How often do mutations occur?

Aaaand there's a big difference in whether the given mutation takes place in a somatic cell or a germ cell - most mutations in somatic ... dystrophy is one such example, causing severe muscular loss that is always lethal, usually as soon as early teens to mid 30s. If the mutation is in a female, ...

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by biohazard
Mon Oct 12, 2009 6:27 am
 
Forum: Genetics
Topic: How often do mutations occur?
Replies: 12
Views: 92

Natural selection is proven wrong

... muscular dystrophy is a rare disease - even though it is common among lethal genetic diseases, you see people suffering from this rarely. And why ... says. Our genes aren't "perfect". They aren't immune to mutations, so even if natural selection would eliminate all "bad" ...

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by biohazard
Thu Apr 23, 2009 10:53 am
 
Forum: Evolution
Topic: Natural selection is proven wrong
Replies: 210
Views: 23384

Sugar Allergy

... Pharm Bull 1990;38(2):430-31. 142. Goto C, Kasuya S, Koga K, et al. Lethal efficacy of extract from Zingiber officinale (traditional Chinese ... Hampe J, Cuthbert A, Croucher JP, et al. Association between insertion mutation in NOD2 gene Crohn's disease in German and British populations. ...

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by DrDahlman
Sat Jan 12, 2008 4:20 pm
 
Forum: Human Biology
Topic: Sugar Allergy
Replies: 71
Views: 70865

Virtual Genetics

... but i dont know how to work out what kind of inheritance it is for the mutation type(autosomal, sex-linked, dominant, recessive, lethal) The numbers are as below. Also is there an easy way to tell what kind of mutation it ...

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by brett86
Tue Sep 04, 2007 3:48 am
 
Forum: Genetics
Topic: Virtual Genetics
Replies: 0
Views: 534

The Fiber Disease

... (reviewed in [1-4]). This is carried out by the MSL (male specific lethal) complex which appears to remodel chromatin architecture by a site-specific ... the other recessive X chromosome in Females that carry the code mutation for Muscular Dystrophy. That is what by dear brother had who will ...

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by Skytroll
Wed Sep 06, 2006 3:45 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 758130
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