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Kinase ii --> peptidyl-dipeptidase a

(Science: enzyme) a hydrolase cleaving C-terminal dipeptides from a variety of substrates, including angiotensin i, which is converted to angiotensin ii and histidylleucine.

An important step in the metabolism of certain vasopressor agents.

It is a chloride-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral ph. Only single dipeptides are released from angiotensin i and bradykinin because of the lack of activity on bonds involving proline. It may also have endopeptidase activity on some substrates.

registry number: EC 3.4.15.1

Synonym: carboxycathepsin, dipeptidyl carboxypeptidase, kinase ii, peptidase P.