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Glutathione

Glutathione

(Science: biochemistry) The tripeptide _ glutamylcysteinylglycine. It contains an unusual peptide Linkage between the _ carboxyl group of the glutamate side chain and the amine group of cysteine.

The concentration of glutathione in animal cells is _5mM and its sulphydryl group is kept largely in the reduced state. This allows it to act as a sulphydryl buffer, reducing any disulphide bonds formed within cytoplasmic proteins to cysteines. Hence, few, if any, cytoplasmic proteins contain disulphide bonds.

glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids and participates in leucotriene synthesis.


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Human aging

... commonly present inside our cells has a high oxidative property and they are also responsible for the formation of hydroxyl radicals. Enzyme like glutathione peroxidase must act on these radicals to prevent the harmful effect to the cells. Nowadays, glutatathione-containing soaps are were widely ...

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by mcar
Fri Jan 09, 2009 9:59 am
 
Forum: Genetics
Topic: Human aging
Replies: 17
Views: 1882

Phytochelatin Synthase and chelation

Phytochelatins are oligomers of Glutathione, so yes they consist of just Glycine, glutamic acid and cysteine. Most organisms in general do not utilize heavy metals, infact they are quiet toxic especially to humans and plants. Plants chelate ...

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by vietknight
Tue Dec 02, 2008 1:37 am
 
Forum: Botany Discussion
Topic: Phytochelatin Synthase and chelation
Replies: 2
Views: 951

Re: Stomach bloating and weight gain

... of the various sulfur-containing amino acids including cysteine, the form called N-acetyl-cysteine, the amino acid methionine and the reduced L-glutathione compound. Asthma and other allergic reactions triggered by the inflammation can be dealt with supplements of the essential vitamin, the ...

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by Jennuan
Wed Oct 29, 2008 4:21 am
 
Forum: Physiology
Topic: Stomach bloating and weight gain
Replies: 299
Views: 484514

ASCII depiction of the antioxidant enzyme defense system

... H2O /\ | | Catalase | oxidases SOD | Fe+2 O2 --------> O2*- --------> H2O2 ----\----> OH* --------> H2O | Fe+3 | | 2GSH | / /\ | Glutathione Glutathione | peroxidase reductase | \/ / | GSSG \/ H2O Figure 1. The Antioxidant Enzyme Defense System Scheme Other publications by Dr. ...

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by ianjager
Fri Sep 19, 2008 8:10 pm
 
Forum: Cell Biology
Topic: ASCII depiction of the antioxidant enzyme defense system
Replies: 1
Views: 620

Potential relationship between non-enzymatic antioxidants

This is the first report regarding quantitation of enzymatic (eg. superoxide dismutase, glutathione reductase & glucose-6-phosphate dehydrogenase) and non-enzymatic (eg. glutathione) antioxidant levels in isolated Leydig cells that I can find in the scientific literature: ...

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by ianjager
Thu Sep 18, 2008 5:08 pm
 
Forum: Cell Biology
Topic: Potential relationship between non-enzymatic antioxidants
Replies: 1
Views: 790
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