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Dictionary » E » Exon

Exon

Definition

noun, plural: exons

(molecular biology)

1. The protein-coding region in the DNA.

2. The nucleic acid sequence in the DNA, or RNA transcript following genetic splicing.


Supplement

Genes contain exons which are regions coding for proteins and which are interrupted by the unused sequences called introns. Exons have been found to include both sequences coding for amino acids and untranslated sequences. The introns are removed and the exons are joined together to form the final functional mRNA.


Related forms: exonic (adjective).
Compare: intron.
See also: DNA, RNA, translation, mRNA, protein synthesis.


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Results from our forum


Intron: Unusual donor-acceptor splice site (GT-AG)

... if the GT-AG sites were intervened with unusual junction sequences (before GT/after AG), for eg: 1. gcgcgggc T GT GCGTC...INTRON...C AG TT gatgc [exon- INTRON -exon] 2. tgaatcagcagg GG GT GCGTC...INTRON...C AG A aagtttatggg [exon- INTRON -exon] Is it because of intron frameshifting/intron sliding? ...

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by molecular09
Wed Jul 01, 2009 8:52 am
 
Forum: Molecular Biology
Topic: Intron: Unusual donor-acceptor splice site (GT-AG)
Replies: 0
Views: 224

Re: Retained Intron through Translation

... by including an intron with a number of bases not evenly divisible by three will also likely bring a stop codon in-frame in the downstream exon, likely also triggering nonsense-mediated decay of the mRNA.

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by jonmoulton
Tue May 05, 2009 11:52 pm
 
Forum: Genetics
Topic: Retained Intron through Translation
Replies: 1
Views: 443

Re: introns and exons

hi canalon, thanks for your hints. i think i know my answer now. ub2 is not a separate gene but the exon that wasn't included in the splicing process. it was annotated as a gene, but may not necessarily a gene. although there is no cDNA in the database encoding for the gene, ...

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by kai85
Wed Apr 01, 2009 5:41 pm
 
Forum: Cell Biology
Topic: introns and exons
Replies: 9
Views: 1328

introns and exons

... Databases show that there are 3 different lengths of cDNA sequences associated with Gene YFG. One of these cDNA sequences has three out of four exons plus additional nucleotide sequence at the 3’ end of the cDNA. This part codes for an extra 123 amino acids. Annotated gene UB2, appears immediately ...

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by canalon
Wed Apr 01, 2009 4:07 pm
 
Forum: Cell Biology
Topic: introns and exons
Replies: 9
Views: 1328

introns and exons

... in my diagram because it appears only after alternative splicing of gene YFG. if i were to include it in the diagram, does it mean that the 1 exon that was not included in the splicing is gene UB2? i also do not understand the last sentence of the question: "There is no cDNA in your database ...

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by kai85
Wed Apr 01, 2009 1:28 pm
 
Forum: Cell Biology
Topic: introns and exons
Replies: 9
Views: 1328
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