Home Forum Dictionary Articles Tutorials Books Directory Share your work


Edit page | Page history | Printable version

Dictionary » D » Dissociation constant

Dissociation constant

Definition

noun

(1) A mathematical constant that describes the tendency of a large molecule to dissociate reversibly into smaller components.

(2) The equilibrium constant in a dissociation reaction.


Supplement

Dissociation constant is a type of equilibrium constant that specifically involves the measure of the propensity of dissociation of a complex molecule into its subcomponents. An example of its application is to describe how tightly a ligand binds to a particular protein.


Also called: equilibrium dissociation constant, ionization constant.

Symbol: Kd

Compare: association constant


Please contribute to this project, if you have more information about this term feel free to edit this page



Results from our forum


How do you calculate dissociation constant?

Kd is one form of an equilibrium constant. You can write a reaction as either a dissociation or association reaction. AB <--> A + B, Kd = [A][B]/[AB] or A + B <--> AB, Keq ...

See entire post
by blcr11
Tue Sep 30, 2008 1:22 am
 
Forum: Molecular Biology
Topic: How do you calculate dissociation constant?
Replies: 11
Views: 2664

Re: How do you calculate dissociation constant?

Kd = ( [P] [ATP])/([P-ATP]) I’m assuming a 1:1 complex of protein with ATP. 10% of your ATP represents 10 mM of bound ATP. But that means that your bound protein concentration is also 10 mM (the bound protein and bound ATP concentrations have to be equal assuming a 1:1 stoichiometry of binding) leav...

See entire post
by blcr11
Mon Sep 29, 2008 5:33 pm
 
Forum: Molecular Biology
Topic: How do you calculate dissociation constant?
Replies: 11
Views: 2664

How do you calculate dissociation constant?

How do you calculate the dissociation constant if 6 mM ATP is present in solution with 10 mM protein, and 20% of the ATP is bound to the protein???

See entire post
by globy123
Mon Sep 29, 2008 4:53 am
 
Forum: Molecular Biology
Topic: How do you calculate dissociation constant?
Replies: 11
Views: 2664

Acid-Base Equilibria & Neutralization

... base, so it won`t completely dissociate. Do we need to use the base dissociation constant called (Kb) to find out "n" moles of water produced?

See entire post
by samoyan
Tue Nov 27, 2007 5:57 am
 
Forum: Molecular Biology
Topic: Acid-Base Equilibria & Neutralization
Replies: 6
Views: 993

Carrier and Channel Proteins

... to the other side The speed of this depends on a number of factors: the dissociation constant of the protein, the size of the protein+ligand, the fluidity of the membrane etc

See entire post
by MrMistery
Mon Sep 24, 2007 10:06 am
 
Forum: Cell Biology
Topic: Carrier and Channel Proteins
Replies: 3
Views: 2855
View all matching forum results

This page was last modified 22:07, 21 January 2009. This page has been accessed 5,445 times. 
What links here | Related changes | Permanent link