Codon nonsense

When an intron is included, you are likely to have a stop codon in-frame in the intron. This triggers nonsense-mediated decay of the mRNA. Frameshifting downstream sequence by including an intron with ...

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well if you only had 21 codons (what's your 21st codon by the way, selenocysteine?) and the rest up until 64 were stop codons, then you would have a lot of nonsense mutations. being degenerate makes a lot of mutations silent.

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... triggering a frameshift that, by introducing a premature stop, triggers nonsense-mediated decay of the transcript. As for your splicing Morpholino, ... stopped" in the figure below). If there is an in-frame stop codon in the intronic sequence, this will likely trigger nonsense-mediated ...

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... you design your oligonucleotides, too. Search Pubmed or google "codon optimization" or "synthetic gene" and you'll get a sampling ... there. Of course, it this isn’t what you’re talking about, this is all nonsense to you.

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Nonsense mutations occur when a point mutations changes a 'sense' codon into a nonsense one and it is followed by translational termination.The protein is not functional.

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