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Serum IgM cannot activate the complement?

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Serum IgM cannot activate the complement?

Postby vaibhavsmarty on Sat Feb 16, 2008 5:21 am

why??????????
four possibilities can be:
a/it does not have complement binding site
b/it is planar in which complement binding sites in the Fc region are not accesible
c/it gets degraded and hence unable to activate the complement
d/it needs metal ions to activate complement
PLZ HELP!!!!!!!!!!!
VaIbHaV tYaGi
where ways seem to be converging call the almighty
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