connexins & pannexins

[theyellowmonster]

hi there i have been given this title to do a powerpoint presentation on!!!


The molecular substrate for electrical synapses in mammalian central nervous system:connexins, pannexins or both?

i am really strugglin with understanding the topic and finding some information to break it down in simpler terms for me!??

can anyone help me at all, as it has to be done by thurs 3rd

[canalon]

If you are ready for something really complete, but probably tough, try this (it's free):

http://www.pnas.org/cgi/content/full/100/23/13644

Otherwise Entrez http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?db=PubMed
has a lot of information (try to search the books database (though I haven't found anything on pannexins) and is always a good starting point.

HTH

Patrick

[theyellowmonster]

hi patrick thanks for that, the pnas link was the reference i already had!! do u know anythin personally about it!!?!?

[canalon]

Sorry, I can't help. In PubMed I found only 6 references to pannexins, and none in the books. If you can acces to the review by Connors & Long, a cursosry reading of the abstract seem to show that it could probably be answering somme of your questions.

And I am a microbiologist, and not particularly knowledgeable about cell structures.

Good luck

Patrick

[theyellowmonster]

which is the connors and long reference sorry??

thanks for your help

[canalon]

which is the connors and long reference sorry??

thanks for your help

ooops sorry

One of the 6 references found in PubMed on pannexins. But you need access to Annual reviews in Neuroscience to go beyond the abstract. I don't.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15217338

HTH

Patrick