erythroblastosis fetalis

[Poison]

I don't think it can.

[victor]

Hey Ozge, I've checked my book and I found it...yes, it's true that only IgG can pass through placenta. The others (IgA, IgM, IgD, IgE) can't pass. But IgM can be formed as the primary immune response.
IgA is the main immunoglobulin from secrets such as saliva, milk, etc...it protects the mukosa from bacterias and viruses.
IgE act as the fast response allergic because it's contained in basophyll
IgD act as the certain antigen response...majority contained in B limphocyte.

[chemistry_freako]

hmms...why is it that only IgG can pass through?

[Poison]

small molecular weight.

[victor]

I think its MW (molecular weight) is 400.000 AMQ (atom mass quantity)

[Poison]

It says that:
IgA :160,000* (Looks small too but it aggregates with higher molecular weights)
IgM: 900,000*
IgG: 150,000*
IgE: 200,000*
IgD: 185,000*

*: Daltons approximately

[victor]

IgA gets in together with milk from their mom..so, no need placenta then..

[Poison]

Yeah. But I haven't seen a mother suckling a fetus.

[victor]

Maybe after this diagram:
Embryo - fetus - [born] - baby

That's when they get the IgA..

[Poison]

Good diagram.

[2810712]

What is the mechanism for IgG to get into the fetus?
Probably it is forced into the blood of fetus though the fenistrations in the maternal capillaries , so the size , shape and molecular wt. all matter.

M I RIGHT???

hrushikesh

[victor]

Or maybe they can be carried out through endocytocys and exocytocys....