IMMUNITY

[2810712]

Hello, I invite U all to participate in this disscussion , please...
T helpers activate B cells and T killers. Is this activation antigen specific ?
hsg

[mayandi venkatesh]

Hello, I invite U all to participate in this disscussion , please...
T helpers activate B cells and T killers. Is this activation antigen specific ?
hsg

I want to some information about autoimmuno diseases , i never get exactly, please reply

[Jelanen]

All activation of adaptive immune response (T-cells and B-cells mainly) is antigen specific. What happens with T-cells is the naive(unactivated) T-cell (CD4--CD8 T-cell will become cytotoxic T-cells if activated) bounces around lymph nodes, constant coming in contact with professional antigen presenting cells. If the naive T-cell happens to come into contact with a antigen:MHC complex that its T-cell receptor binds, then the T-cell is activated and remains in the lymph node. In the lymph node it proliferates and differentiates into effector T-cells. CD4 T-cells can differentiate into either Th1 or Th2 T-cells. Th1 cells work with macrophages in developing a cell-mediated response while Th2 cells work with B-cells in developing an antibody-mediated immune response.

-Jelanen

[2810712]

Ya, this tells that the activation of Th by lymphocytes is Ag specific , but is the activation of B cells and T killers T helpers Ag specific?

And Mayandi , I know some good immunology sites , I will tell you after my exam gets over please...
hrushikesh

[Jelanen]

All activation of adaptive immune response (T-cells and B-cells mainly) is antigen specific

Missed the first sentance?

-Jelanen

[2810712]

Oh sorry,
but I got this question in my mind because I could not find exactly what accounts for this specificity-see Ths activate Tks and B cells simply by secreting interleukenes ; there is no any physical contact bet. Ths and Tks & Ths and B cells , as per I know, then are there several different types of ILs for sewveral Ags???please..........

hrushikesh

[mayandi venkatesh]

All activation of adaptive immune response (T-cells and B-cells mainly) is antigen specific. What happens with T-cells is the naive(unactivated) T-cell (CD4--CD8 T-cell will become cytotoxic T-cells if activated) bounces around lymph nodes, constant coming in contact with professional antigen presenting cells. If the naive T-cell happens to come into contact with a antigen:MHC complex that its T-cell receptor binds, then the T-cell is activated and remains in the lymph node. In the lymph node it proliferates and differentiates into effector T-cells. CD4 T-cells can differentiate into either Th1 or Th2 T-cells. Th1 cells work with macrophages in developing a cell-mediated response while Th2 cells work with B-cells in developing an antibody-mediated immune response.

-Jelanen

Hello, guys , thank ufor ur information