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DNA-binding molecules

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DNA-binding molecules

Postby Lurrena » Tue Mar 24, 2009 12:40 am

Explain how DNA-binding proteins can make sequence specific contacts to a double stranded
DNA molecule without breaking the hydrogen bonds that hold the bases
together.

Anyone got the answer to this?
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Postby MrMistery » Wed Mar 25, 2009 4:01 am

when we were discussing DNA-binding proteins a teaching assistant in my molecular bio course gave us the following joke.
"I make naked DNA bend over and insert my beta sheet into its minor groove. Who am I?" though that's not the regular way this takes place, it was very entertaining.
"I have no intention of stopping anytime soon. I want to understand the universe and answer the big questions, that is what keeps me going" - Stephen Hawking
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Postby plasmodesmata11 » Wed Mar 25, 2009 6:46 pm

heard of leucine zippers and zinc fingers? google that.
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