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Do Competitive Inhibitors slow down enzyme activity?

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Do Competitive Inhibitors slow down enzyme activity?

Postby Funkfruit » Sun Jan 04, 2009 11:18 pm

I read somewhere in my text that Non-Competitive Inhibitors will reduce the maximum rate of a chemical reaction without changing apparent binding affinity of the catalyst or the substrate... I'm curious as to what lines are followed by Competitive Inhibitors. Do they slow down or speed up enzyme activity? If not, what is it that they do?
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Postby blcr11 » Mon Jan 05, 2009 2:02 am

Classical competitive inhibitors compete with substrate for the active site. They lower activity by lowering the apparent affinity of the enzyme toward substrate. That shows up kinetically as an increase in the apparent Km.
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