ASCII depiction of the antioxidant enzyme defense system

[ianjager]

Please forgive, but I lifted this abbreviated antioxidant enzyme
defense system (in ASCII form) scheme from Dr. Mark Kukucka's PhD
dissertation because I couldn't find anything else like it online!

Mechanisms by which hypoxia augments Leydig cell viability and
differentiated cell function in vitro


by Mark A. Kukucka, MS, DVM, PhD


Department of Biomedical Sciences
Virginia-Maryland Regional College of Veterinary Medicine
Virginia Polytechnic Institute & State University
Blacksburg, Virginia 24061-0442


found at:
http://scholar.lib.vt.edu/theses/availa ... 08-170416/

Code: Select all

                             H2O
                             /\
                              |
                              |  Catalase
                              |
   oxidases         SOD       |  Fe+2
O2 --------> O2*- --------> H2O2 ----\----> OH* --------> H2O
                              |        Fe+3
                              |
                              |               2GSH
                              |            /         /\
                              |  Glutathione     Glutathione
                              |   peroxidase      reductase
                              |            \/         /
                              |               GSSG
                             \/
                             H2O


Figure 1. The Antioxidant Enzyme Defense System Scheme


Other publications by Dr. Mark A. Kukucka
http://www.nextbio.com/b/literature/lit ... MA+Kukucka

[MrMistery]

that's actually not such a clear depiction if you ask me. When I originally learned this stuff from my Lehninger Biochemistry I understood it perfectly. From that, if I didn't know the material, I would have a pretty hard time.