erythroblastosis fetalis

[MrMistery]

Same as the second

[2810712]

Please, try to understand my q.
See, the antibodies are present in the maternal blood and very less maternal blood mixes with the fetal blood . So, less feto- RBCs would be killed due to direct mixing of blood.
But i wonder if the antibodies may get flushed into the fetal blood-vessels near placenta due to pressure. If the pressure and offcourse the concentration of these Abs in maternal blood is large enough to have enough Abs flushed into fetal blood then fetus may die due to erythroblastosis. But all this is my hypothesis, is it correct???
Have u got my pt...



Please help...

hruusheekeish

[MrMistery]

Man, blood does not mix, but some things, like nutrients and antibodies do cross the placenta

[victor]

And the bold one mentioned above is the main problem whicg cause ErythroFeta.

[2810712]

So, enough no. of Abs get flushed into fetal blood due to pressure through the placental blood vessels and they lead to the erythroblastosis. But , one pt. is that the fetus must not be in a developemental stage to raise immunoresponse agaist the maternal Abs ... otherwise less erythroblastosis will occur . Right???

hrushikesh

[MrMistery]

If you remember your anatomy 101, the immune sistem of the baby is not developed even at birth. The baby takes antibodies from the mother's milk via pinocytosis vesicles

[Poison]

And the bold one mentioned above is the main problem whicg cause ErythroFeta.

Some antibodies can pass. Not all.

[victor]

What do you mean 'some'? what kind of anti that can't pass? the one that has huge molecule structure?

[Poison]

Huge molecule structures cannot pass. IMMSMR, IgG is the only one that can pass form mother to fetus by placenta.

[victor]

Ow....placenta also have its limitation.. hey, you try to use 'IMMSMR' also...that's good...

[Poison]

I liked IMMSMR.

[victor]

Hey how about this..huge molecules can transport through endocytosis can't they??do placenta do endocytosis?..anyway..next time if anyone doubt, just IMMSMR...