Epigenetic silencing of regulatory genes by aberrant methylation contributes to tumorigenesis.

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Biology Articles » Virology » Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cells » Abbreviations

Abbreviations

- Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cells

BL: Burkitt's lymphoma; EBV: Epstein-Barr virus; EBNA: EBV nuclear antigen; LMP: latent membrane protein; NPC: nasopharingeal carcinoma; qRT-PCR: quantitative real-time PCR; RT: retrotranscription.

Competing interests

The author(s) declare that they have no competing interests.

Authors' contributions

SPR carried out cell experiments and qRT-experiments and helped to draft the manuscript. MPR and MB carried out part of the cell experiments and qRT-experiments, participated in the experimental design and data analysis. CB designed and validated the qRT-PCR system for EBV. JAS carried out part of the cell experiments. DN and MB conceived the study, participated in its design and coordination, and drafted the manuscript. All authors read and approved the final manuscript.

Acknowledgements

Supported in part by the League against Cancer of the Kanton of Zurich