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This work represents the first genome-wide analysis of histone acetylation and its …

Biology Articles » Parasitology » Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica » Table 05

Table 05
- Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica

Table 5

E. histolytica genes downregulated by exposure to Trichostatin A.

Probe ID
 GenBank ID
 Description
 Fold-change
 FDR
111.m00118_at
 XM_647540
 leishmaniolysin-related peptidase, putative
 -44.44
 0.00E+00
233.m00105_at
 XM_645153
 hypothetical protein
 -29.24
 0.00E+00
7.m00429_at
 XM_651789
 Beige BEACH domain protein, putative
 -21.88
 8.51E-10
223.m00071_at
 XM_645286
 hypothetical protein
 -10.88
 3.04E-04
31.m00224_at
 XM_650243
 hypothetical protein
 -9.43
 2.76E-03
1.m00712_at
 XM_652408
 hypothetical protein
 -8.62
 1.64E-05
223.m00075_at
 XM_645290
 lipid phosphatase, putative
 -6.71
 1.34E-03
105.m00133_at
 XM_647680
 NADP-dependent alcohol dehydrogenase
 -5.81
 8.19E-05
223.m00077_x_at
 XM_645292
 hypothetical protein
 -5.65
 8.47E-03
585.m00015_s_at
 XM_642978
 conserved hypothetical protein
 -5.52
 1.11E-02
223.m00069_at
 XM_645284
 hypothetical protein
 -5.49
 9.05E-03
223.m00068_at
 XM_645283
 scavenger mRNA decapping enzyme, putative
 -5.24
 2.27E-03
17.m00307_s_at
 XM_651008
 fatty acid elongase, putative
 -5.08
 1.34E-02
234.m00042_at
 XM_645139
 hypothetical protein
 -5.00
 2.34E-02
66.m00150_at
 XM_648887
 high mobility group protein, putative
 -4.78
 3.68E-02
131.m00139_at
 XM_647034
 M-phase inducer phosphatase, putative
 -4.72
 2.36E-02
249.m00083_at
 XM_644976
 hypothetical protein
 -4.44
 3.58E-03
7.m00436_at
 XM_651745
 actobindin homolog, putative
 -4.31
 7.67E-03
223.m00079_at
 XM_645294
 cysteinyl-tRNA synthetase, putative
 -4.20
 1.54E-02
425.m00057_s_at
 XM_643497
 conserved hypothetical protein
 -4.10
 2.14E-02
223.m00070_at
 XM_645285
 protein kinase, putative
 -4.08
 2.28E-02
4.m00636_at
 NA
 pseudogene, galactose-specific adhesin light subunit
 -4.00
 4.34E-02
217.m00081_s_at
 XM_645388
 hypothetical protein
 -3.91
 1.64E-02
92.m00148_s_at
 XM_648072
 conserved hypothetical protein
 -3.88
 4.66E-02
223.m00078_at
 XM_645293
 ribonuclease, putative
 -3.85
 3.89E-02
180.m00114_at
 XM_646068
 hypothetical protein
 -3.73
 1.75E-03
223.m00067_at
 XM_645282
 integral membrane protein, putative
 -3.73
 3.58E-03
223.m00074_at
 XM_645289
 hypothetical protein
 -3.72
 1.80E-02
223.m00076_at
 XM_645291
 hypothetical protein
 -3.42
 9.24E-03
10.m00362_at
 XM_651510
 cysteine proteinase, putative
 -3.41
 3.20E-09
54.m00183_at
 XM_649345
 hypothetical protein
 -3.33
 4.69E-02
242.m00078_s_at
 XM_645064
 cysteine protease 1
 -2.89
 3.47E-03
77.m00173_at
 XM_648536
 hypothetical protein
 -2.76
 2.82E-04
17.m00351_at
 XM_651053
 galactose-inhibitable lectin 35 kda subunit precursor
 -2.75
 2.84E-02
9.m00419_at
 XM_651593
 Fe-hydrogenase, putative
 -2.72
 1.73E-03
52.m00148_at
 XM_649403
 lysozyme, putative
 -2.61
 4.36E-02
154.m00120_at
 XM_646541
 glucosidase II alpha subunit, putative
 -2.57
 3.53E-02
9.m00416_at
 XM_651590
 hypothetical protein
 -2.49
 4.28E-02
47.m00182_at
 XM_649559
 fatty acid elongase, putative
 -2.26
 3.57E-02
22.m00269_s_at
 XM_650745
 hypothetical protein
 -2.19
 2.76E-02
77.m00178_s_at
 XM_648541
 surface antigen ariel1-related
 -2.08
 3.15E-02

The mean trophozoite expression value for E. histolytica 200:NIH strain under standard culture conditions, the fold-change in TSA treated parasites, FDR, GenBank ID number, and gene annotations are shown. Genes in bold have been confirmed by RT-PCR. Genes regulated during trophozoite to cyst development are shown shaded in italics. Additional loci represented by crosshybridizing _s_at probe sets are as follows: 17.m00307_s_at: 17.m00304; 425.m00057_s_at: 10.m00394; 217.m00081_s_at: 20.m00277; 92.m00148_s_at: 250.m00108 and 284.m00087; 242.m00078_s_at: 79.m00156; 77.m00178_s_at: 19.m00343 and 533.m00017.

Ehrenkaufer et al. BMC Genomics 2007 8:216   doi:10.1186/1471-2164-8-216


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