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This work represents the first genome-wide analysis of histone acetylation and its …

Biology Articles » Parasitology » Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica » Conclusion

Conclusion
- Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica

We have used whole-genome expression profiling to demonstrate that E. histolytica 200:NIH trophozoites have dichotomous responses to SCFA and TSA, both histone deacetylase inhibitors. Despite affecting changes in histone acetylation, and in contrast to data from other eukaryotic systems, short chain fatty acids induce minimal transcriptional changes in E. histolytica trophozoites. In contrast, TSA has both a significant effect on histone acetylation and induces transcriptional changes. Importantly the transcriptional pathway modulated by TSA overlaps significantly with the gene expression changes seen with developmental conversion from trophozoites to cysts. This work identifies for the first time a molecular signature of TSA effects on E. histolytica parasites and lays the groundwork for further dissection of the roles of histone acetylation on amebic development.

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