Treatment of two postoperative endophthalmitis cases due to Aspergillus flavus and Scopulariopsis spp. with local and systemic antifungal therapy
Sayime Aydin1, Bulent Ertugrul2, Berna Gultekin3, Guliz Uyar4 and Erkin Kir5
1The Hospital of Dumlupinar University, Department of Ophthalmology, Kutahya, Turkey
2Adnan Menderes University Medical Faculty, Department of Infectious Diseases and Clinical Microbiology, Aydin, Turkey
3Adnan Menderes University Medical Faculty, Department of Microbiology and Clinical Microbiology, Aydin, Turkey
4Adnan Menderes University Medical Faculty, Department of Infectious Diseases and Clinical Microbiology, Aydin, Turkey
5Adnan Menderes University Medical Faculty, Department of Ophthalmology, Aydin, Turkey
Background
Endophthalmitis is the inflammatory response to invasion of the eye with bacteria or fungi. The incidence of endophthalmitis after cataract surgery varies between 0.072–0.13 percent. Treatment of endophthalmitis with fungal etiology is difficult.
Case Presentation
Case 1: A 71-year old male diabetic patient developed postoperative endophthalmitis due to Aspergillus flavus. The patient was treated with topical amphotericin B ophthalmic solution, intravenous (IV) liposomal amphotericin-B and caspofungin following vitrectomy.
Case 2: A 72-year old male cachectic patient developed postoperative endophthalmitis due to Scopulariopsis spp. The patient was treated with topical and IV voriconazole and caspofungin.
Conclusion
Aspergillus spp. are responsible of postoperative fungal endophthalmitis. Endophthalmitis caused by Scopulariopsis spp. is a very rare condition. The two cases were successfully treated with local and systemic antifungal therapy.
BMC Infectious Diseases 2007, 7:87. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
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