table of contents 
Bothrops atrox is responsible for the majority of snakebite accidents in the …
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2-DE: two-dimensional gel electrophoresis, IPG: immobilized pH gradient, CRISP: Cysteine Rich Secretory Proteins, PLA2: phospholipase A2,VEGF: vascular endothelial growth factor, NGF: nerve growth factor, IEF: isoelectric focusing, DTT: dithiotreitol, PMSF: phenylmethyl sulfonyl fluoride, EDTA: ethylenediaminetetraacetic acid.
Competing interests
The author(s) declare that they have no competing interests.
Authors' contributions
RAPG- Participated in 2D-PAGE, protein blotting, data analysis and writing of the manuscript.
Anna S – Peptide mass fingerprinting, MS/MS analysis and database searching.
Andrej S- Database searching and data analysis. Participated in the writing of the manuscript
JLLP- Animal collection, venom sample preparation and general discussion of results
J. P- Optimization of 2D-PAGE conditions and computational image analysis
MVS- Participated in the design of the study, coordination and writing.
CAOR- Experimental design, data analysis and coordination. Preparation of the final version of the manuscript.
All authors read and approved the final manuscript.
Acknowledgements
This work was supported by PADCT /MCT and FINEP (CT-INFRA). A studentship from CAPES was awarded to Rafael A. Pontes Guércio.
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