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HIV prevention research has been fraught with ethical concerns since its inception.


Biology Articles » Bioethics » Microbicide research in developing countries: have we given the ethical concerns due consideration? » References

References
- Microbicide research in developing countries: have we given the ethical concerns due consideration?

  1. Angell M: The ethics of clinical research in the third world.

    N Engl J Med 1997, 337:847-9.

  2. Bloom BR: The Highest Attainable Standard: Ethical Issues in AIDS Vaccines.

    Science 1998, 279:186-188.

  3. Moodley K: HIV Vaccine Trial Participation in South Africa: An ethical assessment.

    J Med & Phil 2002, 27:197-215.

  4. UNAIDS: Ethical Considerations in HIV Preventive Vaccine Research.

    2002.

  5. Roddy RE, Zekeng L, Ryan KA, Tamoufe U, Weir SS, Wong EL: A Conntrolled Trial of Nonoxynol 9 Film to Reduce Male-to-female Transmission of Sexually Transmitted Diseases.

    N Eng J Med 1998, 339:504-510.

  6. Van Damme L, Ramjee G, Alary M, Vuylsteke , Chandeying V, Rees H, Sirivongrangson P, Mukenge-Tshibaka L, Ettiegne-Traore V, Uaheowitchai C, Abdool Karrim SS, Masse B, Perriens J, Laga M: Effectiveness of COL- a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomized controlled trial.

    The Lancet 1492, 360:971-977.

  7. Horwood J: Cellulose sulphate microbicide trial halted.

    The Lancet Infectious Diseases 2007, 7:183.

  8. Elias CJ, Coggins C, Alvarez F, Brache V, Fraser IS, Lacarra M, Lahteenmaki P, Massai R, Mishell DR, Phillips DM, Salvatierra AM: Colposcopic evaluation of a vaginal gel formulation of iota-carrageenan.

    Contraception 1997, 56:387-389.

  9. Mauck CK, Weiner DH, Creinin MD, Barnhart KT, Callahan MM, Bax R: A randomized phase 1 vaginal safety study of three concentrations of C31G vs. extra strength Gynol II.

    Contraception 2000, 70:233-240.

  10. Mayer KH, Peipert J, Fleming T, Fullem A, Moench T, Cu-Uvin S, Bentley M, Chesney M, Rosenberg Z: Safety and Tolerability of Buffergel, a Novel Vaginal Microbicide, in Women in the United States.

    Clin Infect Dis 2001, 31:476-482.

  11. Van de Wijgert J, Fullem A, Kelly C, Mehendale S, Rogpao S, Kumwenda N, Chirenje Z, Joshi S, Taha T, Padian N, Bollinger R, Nelson K: Phase 1 trial of the Topical Microbicide BufferGel: Safety Results from Four International Sites.

    J Acquir Immune Defic Syndr 2001, 26:21-27.

  12. Mayer KH, Karim SA, Kelly C, Maslankowski L, Rees H, Profy AT, for the HIV Prevention Trials Network (HPTN) 020 Protocol Team: Safety and tolerability of vaginal PRO 2000 gel in sexually active HIV-uninfected and abstinent HIV-infected women.

    AIDS 2003, 17:321-329.

  13. Council for International Organizations of Medical Sciences (CIOMS) 1993 International Ethical Guidelines for Biomedical Research Involving Human Subjects

    Geneva

  14. Mayer KH, Maslankowski LA, Gai F, El-Sadr WM, Justman J, Kwiecien A, Masse B, Rooney JF, Soto-Torres L and the HPTN 050 Protocol Team: Safety and tolerability of tenofovir vaginal gel in abstinent and sexually active HIV-infected and uninfected women.

    AIDS 2006, 20:543-551.

  15. Van de Wijgert JH, Khumalo-Sakutukwa GN, Cogins C, Dube SE, Nyamapfeni P, Padian N: Men's attitudes toward vaginal microbicides and microbicide trials in Zimbabwe.

    International Family Planning Perspectives 1999, 25:15-20.

  16. Ramgee G, Gouws E, Andrews A, Myer L, Weber AE: The Acceptability of a Vaginal Microbicide Among South African Men.

    International Family PlanningPerspectives 2001, 27(4):164-170.

  17. Onwujekwe D, Odunukwe N, Njemanze O, Ezeobi P, Gbajabiamila T, Adu R, Akinbami B, Audu R, Idigbe O: Acceptability of vaginal microbicide among Nigerian serodiscordant couples with female negative partner.

    Conference Proceedings Microbicides 2006 Conference Cape Town South Africa 23–26 April 2006

  18. Mzimela M: Acceptability of using a vaginal gel before sex in Umkanyakude District of KwaZulu Natal.

    Conference Proceedings Microbicides 2006 Conference Cape Town South Africa 23–26 April 2006

  19. Orner P, Harries J, Cooper D, Moodley J, Hoffman M, Becker J, McGrory E, Dabash R, Bracken H: Challenges to microbicide introduction in South Africa.

    Social Science and Medicine 2006, 63:968-978.

  20. Green G, Pool R, Harrison S, Hart GJ, Wilkinson J, Nyanzi S, Whitworth JAG: Female control of sexuality: Illusion or reality? Use of vaginal products in southwest Uganda.

    Social Science and Medicine 2001, 52:585-598.

  21. Coggins C, Elias C, Atisook R, Basset MT, Ettiegne-Traore V, Ghys PD, Jenkins-Woelk L, Thongkrajai E, Van Devanter NL: A study of women's preferences regarding the formulation of over-the-counter vaginal spermicides.

    AIDS 1998, 12:1389-1391.

  22. Darroch JE, Frost J: Women's interest in vaginal microbicides.

    Family Planning Perspectives 1999, 31:16-23.

  23. Hofman S: Covert Use of a Vaginal Microbicide: Views of Women Participating in a Phase 1 Trial of Tenofovir Gel (HPTN 050).

    Conference Proceedings Microbicides 2006 Conference Cape Town South Africa 23–26 April 2006

  24. Schwandt M, Morris C, Ferguson A, Ngugi , Moses S: Anal and dry sex in commercial sex work, and relation to risk for sexually transmitted infections and HIV in Meru, Kenya.

    Sexually Transmitted Infections 2006, 82:392-396.

  25. De Zoysa I, Elias CJ, Bentley ME: Ethical challenges in efficacy trials of vaginal microbicides for HIV prevention.

    Am J Public Health 1998, 88:571-575.

  26. Potts M: The ethics of testing microbicides: are we protecting the volunteers or the investigators?

    AIDS 2001, 15:49-53.

  27. Shapiro K, Benatar SR: HIV prevention and global inequality: steps toward improved standards of care.

    J Med Ethics 2005, 31:39-49.

  28. Birnkrant D: Safety Considerations in Microbicide Trials: FDA Perspective.

    Conference Proceedings HPTN Microbicide Safety Consensus Meeting, Bethesda, 1–3 March 2006

  29. World Health Organisation (WHO) Scientific and Ethical Review Group: Guidelines on reproductive heath research and partners'agreement.

  30. Tolley E: Ethical issues related to pregnancy during microbicide trials.

    Conference Proceedings Microbicides 2006 Conference Cape Town South Africa 23–26 April 2006

  31. Smart T: Microbicides 2006: High rates of pregnancy pose challenges for microbicide trials. [http://www.aidsmap.com/en/news/3F76DCE3-83FA-4523-A920-5CB0829DD33A.asp]

  32. Raymond E: Issues related to pregnancies in microbicide effectiveness trials.

    Microbicides 2006 Conference, Cape Town, OB15 2006.

  33. Rountree W: Change in sexual behavior post-pregnancy in the Savvy Ghana trial.

    Microbicides 2006 Conference, Cape Town, OB17 2006.

  34. Schreiber CA: The impact of pregnancy on microbicide clinical trials.

    Microbicides 2006 Conference, Cape Town, PB67 2006.

  35. Abdool Karim Q, Abdool Karim SS, Coovadia HM, Susser M: Informed Consent for HIV Testing in a South African Hospital: Is It Truly Informed and Truly Voluntary?

    American J of Public Health 1998, 88(4):637-40.

  36. Joubert G, Steinberg H, van der Ryst E, Chikobvu P: Consent for Participation in the Bloemfontein Vitamin a Trial: How Informed and Voluntary?

    American J of Public Health 2003, 93(4):582-84.

  37. Moodley K, Pather M, Myer L: Informed Consent: Participants' Knowledge and Perceptions of Influenza Vaccine Trial Involvement in South Africa.

    JME 2005, 31:727-732.

  38. South African Parliament:

    Child Care Act No 74 of 1983.

  39. South African Parliament:

    Children's Act No 38 of 2005.

  40. South African Parliament:

    National Health Act No 61 of 2003.

  41. Govender P: Girls bunk school to cash in on HIV trials.

    Sunday Times 2005.


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