We thank J. Altman and the National Institutes of Health (NIH) Tetramer Core Facility at Emory University for providing mutant pMHC, B. D. Evavold and L. J. Edwards for providing OTI T cells, T. A. Springer for providing LFA-1 expressing K562 cells, N. Jiang for sharing TCR-pMHC interaction data, L. A. Bunimovich for discussions, and S. V. Ekisheva for providing statistical references. This work was supported by NIH Grants AI38282 and AI44902 (to C.Z.) and GM51338 (to D.L.).
Footnotes
Abbreviations: ICAM-1, intercellular adhesion molecule 1; i.i.d., independent and identically distributed; LFA-1, lymphocyte function-associated antigen 1; pMHC, peptide bound to a major histocompatibility complex molecule; TCR, T cell receptor.
To whom correspondence should be addressed. E-mail: cheng.zhu@bme.gatech.edu
Author contributions: V.I.Z. and C.Z. designed research; J.H., F.Z., and Y.-H.C. performed research; D.L. contributed new reagents; V.I.Z. and C.Z. contributed new analytic tools; V.I.Z. and C.Z. analyzed data; and V.I.Z. and C.Z. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission. M.L.D. is a guest editor invited by the Editorial Board.
This article contains supporting information online at www.pnas.org/cgi/content/full/0704811104/DC1.
© 2007 by The National Academy of Sciences of the USA
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