The central nervous system (CNS) is a major dose-limiting organ in clinical …

• Abstract
• Introduction
• Specific cell types in the central nervous system and their function
• Clinical radiation therapy
• Histopathologic changes
• Early gene induction
• Apoptosis
• Inhibition of neurogenesis
• Hypoxia, barrier disruption, and necrosis of the white matter
• ICAM-1
• Cell replacement
• Reducing apoptotic cell death
• Reducing secondary cell death
• Conclusion
• References
• Figure

Biology Articles » Biophysics » Medical Biophysics » Mechanisms of radiation injury to the central nervous system: implications for neuroprotection » Figure

Figure

- Mechanisms of radiation injury to the central nervous system: implications for neuroprotection

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Figure 1. A model of molecular and cellular responses in the irradiated CNS. Neuroprotective interventions can be directed to potentially reversible targets of the injury response. Note that early injury might not be directly related to late neuro-cognitive impairment and necrosis.

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