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The mild benefits in muscle strength experienced by HIBM patients after IVIG …

Biology Articles » Immunobiology » Intravenous immune globulin in hereditary inclusion body myopathy: a pilot study » Tables

Tables
- Intravenous immune globulin in hereditary inclusion body myopathy: a pilot study

Table 1
Laboratory values at baseline, after loading with IVIG (1 g/kg × 2), and at the end of IVIG treatment.

Baseline
 Post-load
 End of study
 Normal range
Patient
 1
 2
 3
 4
 1
 2
 3
 4
 1
 2
 3
 4
Hemoglobin (g/dL)
 13.1
 14.4
 13.2
 14.3
 11.2
 13.8
 11.2
 13
 12.1
 13.8
 12.3
 11.4
 11.1–16.7
WBC (K/uL)
 8.94
 7.57
 7.39
 7.28
 6.82
 6.11
 8.06
 2.99
 6.94
 6.16
 6.34
 4.85
 3.3–9.6
Platelets (K/uL)
 282
 230
 284
 225
 226
 209
 262
 207
 267
 222
 256
 220
 154–380
ESR (mm/h)
 17
 7
 23
 14
 39
 38
 96
 86
 30
 20
 57
 73
 0–42
Creatinine (mg/dL)
 0.3
 0.7
 0.5
 0.4
 0.4
 0.8
 0.6
 0.6
 0.3
 0.7
 0.6
 0.5
 0.7–1.4
BUN (mg/dL)
 15
 14
 12
 13
 12
 7
 8
 8
 16
 15
 13
 17
 8–22
ALT (U/L)
 42
 36
 18
 36
 31
 37
 16
 30
 60
 81
 18
 62
 6–41
AST (U/L)
 30
 31
 22
 23
 21
 31
 15
 23
 36
 68
 31
 52
 9–34
CPK (U/L)
 320
 475
 98
 130
 244
 451
 50
 87
 229
 629
 78
 94
 38–386
Cholesterol (mg/dL)
 195
 203
 195
 207
 133
 153
 144
 156
 168
 179
 175
 170
 100–200
Total protein (g/dL)
 6.4
 6.1
 6.1
 6.3
 7.8
 8.7
 9.5
 9.1
 7.1
 7.2
 7.3
 7
 6.0–7.6
Albumin (g/dL)
 3.7
 3.7
 3.2
 3.5
 2.9
 3.4
 2.6
 3
 3.3
 3.5
 2.8
 3.1
 3.7–4.7
IgG (mg/dL)
 1280
 1180
 955
 997
 3550
 4280
 5670
 4440
 2150
 2350
 2340
 2310
 642–1730
Urine protein (mg/d)
 150
 92
 294
 97
 79
 95
 364
 142
 30–150
Urine glucose (g/d)
 0.07
 0.07
 0.07
 0.09
 14.4
 30.8
 6.4
 12.2
 0.07
 0.07
 0.10
 0.08
 0–0.49
Abnormal values are in bold. Normal range encompasses values for males and females.
Baseline values are average of results on two different days.
Table 2
Strength of muscle groups of 4 HIBM patients at baseline and after IVIG treatment.

Hip Flexion
 Ankle Dorsiflexion
 Elbow
 Wrist
 Hand






Flexion
 Extension
 Flexion
 Extension
 Grip
 Pinch
Baselinea,b
 3.21 ± 0.84
 3.50 ± 2.15
 4.71 ± 1.42
 3.36 ± 1.09
 5.24 ± 0.86
 4.55 ± 0.46
 7.43 ± 1.63
 1.02 ± 0.22
Post-Loadb
 3.93 ± 0.74
(+22%)
 2.53 ± 1.55
(-28%)
 5.56 ± 1.60
(+18%)
 3.30 + 0.98
(-2%)
 5.81 ± 1.07
(+11%)
 5.15 ± 0.58
(+13%)
 7.85 ± 1.65
(+6%)
 1.03 ± 0.16
(+1%)
End of studyb
 3.63 ± 0.62
(+13%)
 4.28 ± 2.87
(+22%)
 5.45 ± 1.55
(+16%)
 3.36 ± 1.03
(0%)
 6.25 ± 1.15
(+19%)
 5.78 ± 0.93
(+27%)
 7.83 ± 1.59
(+5%)
 1.37 ± 0.25
(+35%)
aValues are given in kg as means ± SEM. Percent changes are in parentheses. Values for both the right and left sides were included in the analyses.
bBaseline: Before treatment; Post-Load: Day 1 after IVIG load (1 g/kg × 2); End of study: 4 weeks after the initial IVIG load.

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