The mild benefits in muscle strength experienced by HIBM patients after IVIG …

• Abstract
• Background
• Methods
• Results
• Discussion
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Biology Articles » Immunobiology » Intravenous immune globulin in hereditary inclusion body myopathy: a pilot study » Conclusion

Conclusion

- Intravenous immune globulin in hereditary inclusion body myopathy: a pilot study

Our findings indicate that IVIG treatment has a salutary clinical effect on the myopathy of HIBM. Since HIBM results from defective sialic acid biosynthesis and is not associated with inflammation, the benefits of IVIG treatment could be related to the high sialic acid content of IgG. These results prompt consideration of other sources of sialic acid as therapy for HIBM, and identify suitable outcome parameters for future clinical trials.