Immunohistochemical expression of interleukin 8 in skin biopsies from patients with inflammatory acne vulgaris
Howayda S Abd El All1 , Noha S Shoukry2 , Rabee A El Maged2 and Mostafa M Ayada2
1Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
2Department of Dermatology and Andrology Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Background
This study was conducted to evaluate the immunohistochemical (IHC) expression of interleukin 8 (IL-8) in skin biopsies of inflammatory acne vulgaris (IAV) in an attempt to understand the disease pathogenesis.
Materials and methods
A total of 58 biopsies, 29 from lesional IAV and 29 normal non lesional sites were immunostained for IL-8. The intensity of staining was evaluated in the epidermis and dermis and was scored as mild, moderate and severe. The expression was correlated with the clinical grade, disease course and histological changes.
Results
IL-8 immunoreactivity was expressed in lesional IAV compared to non lesional skin biopsies (p
Conclusion
We were able to demonstrate altered immunoreactivity of IL-8 in IAV compared to normal skin. Targeted therapy to block IL-8 production may hold promise in limiting the deleterious effects of IL-8-mediated inflammatory response and angiogenesis.
Diagnostic Pathology 2007, 2:4. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
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