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The objective of this study was to identify the molecular processes responsible …

Biology Articles » Immunobiology » Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream » Table

Table
- Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream

Table 1
Gene Ontology Classification of Imiquimod-Induced Genes in AK Lesions
Ontology
 Genes in the Data1
 Annotated Genes2
 P-value3
 Increased Expression
 Decreased Expression
 Description of Processes and Specific Genes
Total
 436
 17479
369
 67
Response to stimuli
 137
 2475
 2.13E-19
 125
 12
 defense response, response to external biotic stimuli including, pest and pathogens, antimicrobial, anti-fungal, anti-viral response
Defense response
 105
 1174
 1.54E-40
 102
 3
 immune response, inflammatory response
Immune response
 106
 1020
 3.05E-40
 104
 2
 cellular defense response, humoral defense response, antigen binding, pattern binding, cytokine synthesis, chemokine synthesis, antigen presentation processing, inflammatory response
Response to stress
 68
 1337
 1.77E-12
 63
 5
 response to pest and pathogen, inflammatory response, response to virus, response to wounding
Inflammatory response
 25
 244
 4.35E-11
 25
 0
 defensive reaction (by vertebrate tissue) to infection or injury
Response to wounding
 39
 395
 3.72E-16
 39
 0
 defensive reaction (by vertebrate tissue) to physical injury
Signal transduction
 123
 3547
 4.70E-06
 95
 17
 cytokine signaling, death receptor signaling, G-protein coupled receptor signaling, intigrin binding, MHC protein binding
Receptor activity
 72
 1914
 1.80E-07
 62
 10
 chemokine receptors, pattern recognition receptors, immunoglobulin receptors, complement receptors, MHC I\MHCII receptors, scavenger receptors, Hematopoietin/interferon class (D200) receptors
Antigen binding
 8
 91
 2.66E-03
 8
 0
 SCF1, IGLV2-14, LAG3, LILRA1, SLAMF1, TRA@, TRGC2, TAP2
Carbohydrate binding
 16
 326
 1.18E-03
 14
 2
 CCL8, CD69, CLEC4A, FCN1, FGFR2, GALNT7, HMMR, KLRC1/KLRC2, KLRF1, LGALS2, LGALS9, POSTN, PTN, SELL, SELPLG, SN
Pattern binding
 10
 159
 4.58E-02
 8
 2
 CCL8, CD14, FGFR2, HMMR, POSTN, PTN, TLR2, TLR7, TLR8, TLR4
Cytokine receptors
 9
 99
 1.97E-04
 9
 0
 CCR5, CCR1, CD74, CSF2RB, CXCR4, IL10RA, IL1RL1, IL21R, TNFRSF1B
Cytokines
 12
 257
 1.11E-04
 11
 1
 CCL3, CCL5, CCL8, CXCL5, CXCL10, CXCL11, CXCL12, CXCL16, TNFSF10, ECGF1, PTN, SLURP1
Immunoglobulin binding
 4
 25
 1.56E-03
 4
 0
 FCER1A, FCER1G, FCGR3B, 214511_x_at
Cystein type endopeptidase
 9
 169
 8.21E-03
 9
 0
 CASP1, CASP8, CTSB, CTSL, CTSC, STSS, LGMN, TNFAIP3, USP18
1Number of genes in the data for which annotation was found in the Gene Ontology database.
2Total number of gene with annotation in the Gene Ontology database.
3P-value for representation of gene ontology category in the data.

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