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The study evaluated the feasibility of long-term cryopreservation of ovarian tissue in …

Biology Articles » Cryobiology » Human ovarian tissue cryopreservation: indications and feasibility » Tables

Tables
- Human ovarian tissue cryopreservation: indications and feasibility

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Table I. Characteristics and follow-up of the 31 patients who had an ovarian tissue cryopreservation

Case no. Pathology Age (years) Marital status Previous chemotherapy Surgical acts associated Volume of ovarian tissue collected No. of cryopreserved fragments Primordial and primary follicles (no./mm2) Follow-up
    1 Sickle cell disease 13 No Yes Half ovary 17  0.71 Healthy
    2 Myelodysplasia 21 Stable relationship No No Whole ovary 21  0 Deceased
    3 Hodgkin's disease 17.3 No No Half ovary 23  0 Healthy
    4 Hodgkin's disease 26.4 Married, one baby No Yes Half ovary 16  0.31 Recurrence
    5 Neuroblastoma  4 Yes Yes Half ovary 13 29.67 Deceased
    6 Leukaemia 27 Single Yes No Whole ovary 30  1.87 Healthy
    7 Hodgkin's disease 20 Single Yes No Whole ovary 26  1.80 NK
    8 Ewing sarcoma 12.5 Yes No Whole ovary 21  6 Deceased
    9 Neuroblastoma  2.7 Yes Yes Whole ovary 24 26.5 Deceased
10 Neuroblastoma 14.3 Yes No Whole ovary 24  4.25 Healthy
11 Sickle cell disease 12.4 No No Whole ovary 21  8.5 Healthy
12 Acute leukaemia  6.1 Yes No Whole ovary 15  0 Deceased
13 Lymphoma 34 Single No No Half ovary 15  1.33 Healthy
14 Lymphoma 29 Married Yes No Whole ovary 25  0.6 Healthy
15 Ewing sarcoma 24.3 Married Yes No Whole ovary 23  0.29 Deceased
16 Ewing sarcoma 24.6 Married Yes No Whole ovary 50  0.8 Healthy
17 Sickle cell disease 14.2 No Yes Whole ovary 23  3.67 Healthy
18 Hodgkin's disease 33.1 Single Yes No Whole ovary 27  2.23 Recurrence
19 Acute leukaemia 16.7 Yes No Whole ovary 26  1 Deceased
20 Peritoneal borderline tumour 20.6 Single No Yes Two half ovaries 36  0.67 Healthy
21 Acute leukaemia 11.6 Yes Yes Whole ovary 25  1 Healthy
22 Breast cancer 32.3 Stable relationship No No Half ovary 20  0 Healthy
23 Hodgkin's disease 23.7 Single Yes No Half ovary 32 14.25 NK
24 Ewing sarcoma 12.2 Yes No Whole ovary 31  7.5 NK
25 Neuroblastoma  3.2 Yes No Whole ovary 27 15.75 NK
26 Medulloblastoma  6.3 Yes No Whole ovary 32 49.67 Deceased
27 Acute leukaemia 14.9 Yes No Whole ovary 40  1.45 Deceased
28 Hodgkin's disease 28 Stable relationship Yes No Whole ovary 36  2.5 NK
29 Medulloblastoma  4.3 Yes No Whole ovary 24  0.56 NK
30 Hodgkin's disease 18.6 Single Yes No Whole ovary 39  0.09 NK
31 Hodgkin's disease 27 Single Yes No Whole ovary 30  0.02 NK
NK = not known.


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Table II. Details of the 20 cases in which no ovarian cryopreservation was done

Case Pathology Age (years) Marital status Previous chemotherapy Reason
A Eosinophil granuloma 16 Single No No gonadotoxic treatment
B Eosinophil granuloma 18 Single No No gonadotoxic treatment
C ORL lymphoepithelioma 24.9 Married, 1 child No No gonadotoxic treatment
D Non-Hodgkin lymphoma recurrence 32.7 Married, 2 children Yes Premature ovarian failure
E Hodgkin's disease 41.8 Stable relationship No Age
F Hodgkin's disease 33.5 Single Yes Premature ovarian failure
G Nephrotic syndrome 36.9 Married, 1 child No No gonadotoxic treatment
H Chronic lymphoid leukaemia 28.4 Stable relationship No Pregnancy
I Hodgkin's disease 24 Single Yes Premature ovarian failure
J Breast cancer 35.1 Married No Patient declined
K Ovarian borderline tumour 25.6 Stable relationship No No safe ovarian tissue
L Hodgkin's disease recurrence 25 Married Yes IVF attempt
M Mediastinal lymphoma 24.1 Single Yes Patient declined
N Ovarian teratoma 16 No No ovarian tissue collection
O Ovarian borderline tumour 29.3 Stable relationship No Normal tumoral markers
P Sickle cell disease  5.6 No Anesthesic declined
Q Medulloblastoma  1 Yes Parent declined
R Breast cancer 38.5 Stable relationship No Age
S Breast cancer 42.1 Stable relationship No Age
T Medulloblastoma  2.5 Yes No gonadotoxic treatment
ORL = otorhinolaryngological.


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Source: Human Reproduction, Vol. 17, No. 6, 1447-1452, June 2002.


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