They are ideal tools for comparative genomic studies aimed at understanding how …

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Biology Articles » Evolutionary Biology » Human Evolution » Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization » Conclusion

Conclusion

- Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization

Using comparative genomics, we defined the YRG family as a unique group of circularly permuted GTPases. We suggest a potential function for this family, as well as a potential pathway by which the family members may act sequentially, following an evolutionary process linked to compartimentalization (Figure 6). A future goal will be to test this hypothesis experimentally and to dissect the molecular mechanisms of action of each member of the pathway.