The authors show that the transcription factor Sp8 has an essential role …

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Biology Articles » Developmental Biology » Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain » Conclusion

Conclusion

- Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain

Our findings provide evidence that the transcription factor Sp8 is required for both the early patterning of the forebrain and the specification and survival of ventral cell types of the telencephalon. Our findings support the idea that a direct interaction between Sp8 and Emx2 controls D/V patterning of the medial telencephalon, functional arealization along the A/P axis, and the specification of subpopulations of cortical layers.