The genotyping protocols used in this study may be useful for differentiating …

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Biology Articles » Parasitology » Genetic diversity of Plasmodium vivax in Kolkata, India » Conclusion

Conclusion

- Genetic diversity of Plasmodium vivax in Kolkata, India

When genotyped using three polymorphic markers (pvcs, pvmsp1 and pvmsp3-alpha)P. vivax infections in Kolkata demonstrate a low rate of multiple genotype infection despite a high degree of genetic diversity. Given the degree of diversity found genotyping methods such as these are likely to be of value in distinguishing relapse/recurrence from reinfection in clinical trials of antimalarial drug efficacy.


Authors' contributions


JRK was involved in all stages of this study. SP and AN designed the study and were responsible for the day-to-day supervision of patient recruitment and clinical management. MI was responsible for the supervision of the molecular genetic study and NT for the laboratory work. AM and MA participated in the recruiting of patients. KC and APN participated in the coordination of laboratory work. NJW and NPD helped compose the manuscript and gave constructive advice. All authors read and approved this final manuscript.


Acknowledgements


We thank Kasia Stepniewska for statistical advice. Some laboratory tests were done at the Centre of Tropical Medicine and Parasitology, Kolkata. This study was part of the Wellcome Trust-Mahidol University, Oxford Tropical Medicine Research Programme funded by the Wellcome Trust of Great Britain. Financial support was provided by a Wellcome Trust fellowship to MI (reference No. 066439/2/01/2).