A screen for mutants that developed an exaggerated cell death response following …

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Biology Articles » Mycology » EDR2 negatively regulates salicylic acid-based defenses and cell death during powdery mildew infections of Arabidopsis thaliana » Conclusion

Conclusion

- EDR2 negatively regulates salicylic acid-based defenses and cell death during powdery mildew infections of Arabidopsis thaliana

EDR2 was isolated as a negative regulator of cell death, specifically the cell death elicited by pathogen attack but not by abiotic stresses. EDR2 encodes a novel protein with PH, START and DUF1336 domains. The PH domain of EDR2 binds preferentially to PI-4-P and the EDR2 protein localizes to endosomes, the endoplasmic reticulum and the plasma membrane. The lesions that develop in edr2 mutants are dependent on the SA signal transduction pathway providing an additional link to defense responses. Thus, it is possible that EDR2 or possibly a lipid/sterol product acts in opposition to the SA pathway to fine tune the HR.