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The authors present a statistical model for mapping and characterizing specific genes …

Biology Articles » Chronobiology » A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms » Tables

Tables
- A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms

Table 1

The MLEs of parameters that define circadian rhythms for three different QTL genotypes, the structure of the covariance matrix and the association between the marker and QTL in a natural population, taking the heritability of the assumed QTL as H2 = 0.1. The numbers in parentheses are the square roots of the mean square errors of the MLEs.

Rhythmic Parameters
AA Aa aa
Given MLE Given MLE Given MLE
n 1.50 1.57(0.067) 1.40 1.54(0.139) 1.70 1.74(0.045)
m 3.00 3.02(0.018) 2.90 2.91(0.010) 2.80 2.79(0.050)
rM 1.10 1.16(0.060) 1.30 1.35(0.054) 0.90 0.98(0.083)
rP 0.30 0.30(0.020) 0.35 0.36(0.007) 0.40 0.39(0.001)
qM 0.16 0.15(0.008) 0.17 0.16(0.011) 0.18 0.17(0.012)
qP 0.16 0.16(0.001) 0.17 0.16(0.005) 0.18 0.18(0.001)
Matrix Structuring Parameters
Given MLE
[var phi]x 0.010 0.011(0.001)
[var phi]y -0.100 0.098(0.001)
ψx 0.100 0.105(0.005)
ψy -0.200 -0.206(0.006)
equation M27 0.223 0.223(0.001)
equation M28 1.842 1.742(0.100)
ρ 0.200 0.216(0.016)
Genetic Parameters
Given MLE
p 0.6 0.601(0.003)
q 0.6 0.501(0.094)
D 0.08 0.068(0.012)
Table 2

The MLEs of parameters that define circadian rhythms for three different QTL genotypes, the structure of the covariance matrix and the association between the marker and QTL in a natural population, taking the heritability of the assumed QTL as H2 = 0.4. The numbers in parentheses are the square roots of the mean square errors of the MLEs.

Rhythmic Parameters
AA Aa aa
Given MLE Given MLE Given MLE
n 1.50 1.52(0.059) 1.40 1.42(0.006) 1.70 1.71(0.060)
m 3.00 3.02(0.015) 2.90 2.90(0.009) 2.80 2.80(0.020)
rM 1.10 1.14(0.052) 1.30 1.34(0.028) 0.90 0.93(0.066)
rP 0.30 0.30(0.009) 0.35 0.35(0.002) 0.40 0.40(0.001)
qM 0.16 0.16(0.003) 0.17 0.17(0.011) 0.18 0.18(0.005)
qP 0.16 0.16(0.004) 0.17 0.17(0.003) 0.18 0.18(0.001)
Matrix Structuring Parameters
Given MLE
[var phi]x 0.010 0.010(0.001)
[var phi]y -0.100 0.095(0.002)
ψx 0.100 0.102(0.005)
ψy -0.200 0.201(0.006)
equation M29 0.307 0.309(0.011)
equation M30 0.200 0.204(0.011)
ρ 0.037 0.038(0.002)
Genetic Parameters
Given MLE
p 0.6 0.601(0.002)
q 0.6 0.67(0.091)
D 0.08 0.067(0.022)

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