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Biology Articles » Chronobiology » A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms » Figures

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- A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms

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Figure 1

(A) Diagram of the biological elements of the protein synthesis cascade for a circadian rhythm generator. (B) Model interpretation of A showing the delay (τ) and nonlinearity in the protein production cascade, the nonlinear negative feedback, and mRNA and protein production (r_M, r_P) and degradation (q_M, q_P). Adapted from ref. [10].

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Figure 2

Free-running oscillation of mRNA abundance (x) and protein abundance (y) in a rhythmic system, expressed as limit cycle contour, annotated with the time points within the 24.6 h circadian cycle, for three assumed QTL genotypes using given rhythmic parameter values (A), estimated values under H²= 0.1 (B), and estimated values under H²= 0.4 (C). The three plots within each column correspond to QTL genotypes AA, Aa and aa, respectively.